People

Prof. Dr. Andreas Schmid

Prof. Dr. Andreas Schmid
Prof. Dr. Andreas Schmid
Department of Solar Materials
Helmholtz Centre for Environmental Research
Kubus, Room 406
Permoserstraße 15, 04318 Leipzig
Germany

Tel.: +49-341-235 12 86 (secretary)
Fax.: +49-341-235 45 12 46

E-Mail:



Resume

Andreas Schmid (* June 27, 1966)

Education

1997 Dr. rer.nat., University of Stuttgart, Stuttgart, Germany.
1992
 Dipl.-Biol. (microbiology, biochemistry) University of Stuttgart, Stuttgart, Germany.
2004 Habilitation, Swiss Federal Institute of Technology (ETHZ); venia legendi for Microbiology and Biotechnology.
1996-1998 Postdoctoral Research Associate, Institute of Biotechnology, Swiss Federal Institute of Technology (ETHZ), Zurich, Switzerland; Area: Biocatalysis, Project acquisitions from chemical & pharmaceutical companies, Evaluation 'Spinoff Company' in the field of biocatalysis / chemical process development.

Positions

Since 10/2014 Head of Department Solar Materials at the Helmholz Centre for Environmental Research (UFZ), Leipzig, Germany.
2004 - 2014 Professor, Chair, Laboratory of Chemical Biotechnology, Department of Biochemical & Chemical Engineering, TU Dortmund University, Dortmund, Germany.
2005 - 2011 Head Single Cell Laboratory at Leibniz Institut für Analytische Wissenschaften ISAS-e.V., Dortmund, Germany.
1999-2004 Group Leader, Head of ‘Technical Enzymology' Laboratory, Institute of Biotechnology (IBT, Prof. Dr. Bernard Witholt), Swiss Federal Institute of Technology, ETH Hoenggerberg, Zurich, Switzerland.
1996-1998 Post Doctoral Fellow Institute of Biotechnology, ETH Hönggerberg, Zürich, Switzerland. with Prof. Dr. B. Witholt.
1995-1996 Vice Head of the Department of Biological Waste Air Treatment, Institute for Sanitary Engineering, Water Quality and Solid Waste Management (ISWA), University of Stuttgart, Stuttgart, Germany. with Prof. Dr. K.-H. Engesser.
1995-1996 Visiting Scientist Department of Microbiology, Swiss Federal Institute for Environmental Science and Technology, EAWAG, Dübendorf, Switzerland. with Dr. J. R. v.d. Meer, Prof. A. Zehnder.
1994-1995 Staff scientist, Department of Biological Waste Air Treatment, Institute for Sanitary Engineering, Water Quality and Solid Waste Management (ISWA), University of Stuttgart, Stuttgart, Germany.

Since 2006 Coordinator of 'ChemBioTec' (www.chembiotec.de), research network of Deutsche Bundesstiftung Umwelt). 2006 Visiting professor (JSPS, Japan). 2011 Visiting professor, AIBN, University of Queensland (Brisbane, Australia).

Research areas

Single cell analysis, nano- and microreactors, catalytic biofilms, (continuous) redox biocatalysis using whole cells and isolated enzymes, highly productive and specific oxyfunctionalizations of hydrocarbons by means of microbial cells, systems biotechnology in Escherichia coli, Pseudomonas putida and yeast, sustainability.



Publications
Peer Reviewed Articles
2016
  • Oehling V., Klaassen P., Schmid A. and Frick O. (2016)
    Arabinose triggers its own uptake via induction of the arabinose specific Gal2p transporter in an arabinose fermenting Saccharomyces cerevisiae strain.
    Submitted
  • Köhler K. A. K., Blank L. M., Ebert B. E., Rückert C., Kalinowski J. and Schmid A. (2016)
    Genome and physiology of Pseudomonas taiwanensis strain VLB120 reveal a new chassis for industrial biotechnology.
    Submitted
  • Schmutzler K., Kupitz K., Schmid A. and Bühler K. (2016)
    Hyperadherence of Pseudomonas taiwanensis VLB120ΔC increases productivity of (S)-styrene oxide formation.
    Submitted
  • Rosenthal K.*, Oehling V.*, Dusny C. and Schmid A. (2016)
    Understanding isolated microbial single cells.
    Submitted
    * These authors contributed equally to this work.
  • Kadisch M., Julsing M. K., Schrewe M., Jehmlich N., Scheer B., von Bergen M., Schmid A. and Bühler B. (2016)
    Cell viability rather than enzyme kinetics determines whole-cell ω-oxyfunctionalization performance.
    Biotechnology & Bioengineering, Accepted
  • Karande R., Debor L., Salamanca D., Bogdahn F., Engesser K.-H., Bühler K. and Schmid A. (2016)
    Continuous cyclohexane oxidation to cyclohexanol using a novel cytochrome P450 monooxygenase from Acidovorax sp. CHX100 in recombinant P. taiwanensis VLB120 biofilms.
    Biotechnology and Bioengineering, 113(1):52-61, DOI-Link
  • Willrodt C., Hoschek A., Bühler B., Schmid A. and Julsing M. K. (2016)
    Decoupling production from growth by magnesium sulfate limitation boosts de novo limonene production.
    Biotechnology and Bioengineering, 113(6):1305-1314, DOI-Link
  • Sudarsan S., Blank L. M., Dietrich A, Vielhauer O, Takors R, Schmid A. and Reuss M. (2016)
    Dynamics of benzoate metabolism in Pseudomonas putida KT2440.
    3:97-110
  • Ladkau N., Aßmann M., Schrewe M., Julsing M. K., Schmid A. and Bühler B. (2016)
    Efficient production of the Nylon 12 monomer ω-aminododecanoic acid methyl ester from renewable dodecanoic acid methyl ester with engineered Escherichia coli.
    Metabolic Engineering, 36:1-9, DOI-Link
  • Schmutzler K., Kracht O., Schmid A. and Bühler K. (2016)
    Trophic regulation of autoaggregation in Pseudomonas taiwanensis VLB120.
    Applied Microbiology and Biotechnology, 100(1):347-360, DOI-Link
2015
  • Lange K., Schmid A. and Julsing M. K. (2015)
    Δ-9-Tetrahydrocannabinolic acid synthase production in Pichia pastoris enables chemical synthesis of cannabinoids .
    Journal of Biotechnology, 211:68–76, DOI-Link
  • Lange K., Poetsch A., Schmid A. and Julsing M. K. (2015)
    Enrichment and identification of Δ-9-tetrahydrocannabinolic acid synthase from Pichia pastoris culture supernatants
    .
    Data in Brief, 4:641-649, DOI-Link, Pubmed
  • Schmutzler K., Schmid A. and Bühler K. (2015)
    A three step method for analysing bacterial biofilm formation under continuous medium flow.
    Applied Microbiology and Biotechnology, 99(14):6035-6047, DOI-Link
  • Rosenthal K., Falke F., Frick O., Dusny C. and Schmid A. (2015)
    An inert continuous microreactor for the isolation and analysis of a single microbial cell.
    Micromachines, 6(12):1836-1855, DOI-Link
  • Dusny C. and Schmid A. (2015)
    Challenging biological limits with microfluidic single cell analysis.
    Microbial Biotechnology, 8(1):23-25, DOI-Link
  • Willrodt C., Hoschek A., Bühler B., Schmid A. and Julsing M. K. (2015)
    Coupling limonene formation and oxyfunctionalization by mixed-culture resting cell fermentation.
    Biotechnology & Bioengineering, 112(9):1738-1750, DOI-Link
  • Köhler K. A. K., Blank L. M., Frick O. and Schmid A. (2015)
    D-Xylose assimilation via the Weimberg pathway by solvent tolerant Pseudomonas taiwanensis VLB120.
    Environmental Microbiology, 17(1):156-170, DOI-Link
  • Looße C., Galozzi S., Debor L., Julsing M. K., Bühler B., Schmid A., Barkovits K., Müller T. and Marcus K. (2015)
    Direct infusion-SIM as fast and robust method for absolute protein quantification in complex samples.
    EuPA Open Proteomics, 7:20-26, DOI-Link
  • Falcioni F., Bühler B. and Schmid A. (2015)
    Efficient hydroxyproline production from glucose in minimal media by Corynebacterium glutamicum.
    Biotechnology and Bioengineering, 112(2):322-330, DOI-Link
  • Volmer J., Schmid A. and Bühler B. (2015)
    Guiding bioprocess design by microbial ecology.
    Current Opinion in Microbiology, 25:25-32, DOI-Link
  • Willrodt C., Karande R., Schmid A. and Julsing M. K. (2015)
    Guiding efficient microbial synthesis of non-natural chemicals by physicochemical properties of reactants.
    Current Opinion in Biotechnology, 35:52-62, DOI-Link
  • Köhler K. A. K., Rühl J., Blank L. M. and Schmid A. (2015)
    Integration of biocatalyst and process engineering for sustainable und efficient n-butanol production.
    Engineering in Life Sciences, 15(1):4-19, DOI-Link
  • Lindmeyer M., Meyer D., Kuhn D., Bühler B. and Schmid A. (2015)
    Making variability less variable: matching expression system and host for oxygenase-based biotransformations.
    Journal of Industrial Microbiology and Biotechnology, 42(6):851-866, DOI-Link
  • Theodosiou E., Frick O., Bühler B. and Schmid A. (2015)
    Metabolic network capacity of Escherichia coli for Krebs cycle-dependent proline hydroxylation.
    Microbial Cell Factories, 14:108, DOI-Link
  • Dusny C. and Schmid A. (2015)
    Microfluidic single cell analysis links boundary environments and individual microbial phenotypes.
    Environmental Microbiology, 17(6):1839-1856, DOI-Link
  • Lang K., Bühler K. and Schmid A. (2015)
    Multistep synthesis of (S)-3-hydroxyisobutyric acid from glucose using Pseudomonas taiwanensis VLB120 catalytic biofilms.
    Advanced Synthesis and Catalysis, 357(8):1919-1927, DOI-Link
  • Salamanca D., Karande R., Schmid A. and Dobslaw D. (2015)
    Novel cyclohexane monooxygenase from Acidovorax sp. CHX100.
    Applied Microbiology and Biotechnology, 99(16):6889-6897, DOI-Link
  • Brandenbusch C., Collins J., Glonke S., Hoffrogge R., Grunwald K., Bühler B., Schmid A. and Sadowski G. (2015)
    Process boundaries of irreversible scCO2-assisted phase separation in biphasic whole-cell biocatalysis.
    Biotechnology and Bioengineering, 112(11):2316-2323, DOI-Link
  • David C., Bühler K. and Schmid A. (2015)
    Stabilization of single species Synechocystis biofilms by cultivation under segmented flow .
    Journal of Industrial Biotechnology, 42(7):1083-1089, DOI-Link
  • Dusny C., Grünberger A., Probst C., Wiechert W., Kohlheyer D. and Schmid A. (2015)
    Technical bias of microcultivation environments on single cell physiology.
    Lab Chip, 15:1822-1834, DOI-Link
  • Collins J., Grund M., Brandenbusch C., Sadowski G., Schmid A. and Bühler B. (2015)
    The dynamic influence of cells on the formation of stable emulsions in organic-aqueous biotransformations.
    Journal of Industrial Microbiology and Biotechnology, 42(7):1011-1026, DOI-Link
  • Lindmeyer M., Jahn M., Vorpahl C., Müller S., Schmid A. and Bühler B. (2015)
    Variability in subpopulation formation propagates into biocatalytic variability of engineered Pseudomonas putida strains.
    Frontiers in Microbiology, 6:1042, DOI-Link
2014
  • Tomaszewski B., Schmid A. and Bühler K. (2014)
    Biocatalytic production of catechols using a high pressure tube-in-tube segmented flow microreactor.
    Organic Process Research & Development, 18(11):1516–1526, DOI-Link
  • Ruinatscha R., Bühler K. and Schmid A. (2014)
    Development of a high performance electrochemical cofactor regeneration modul and its application for the continuos reduction of FAD.
    Journal of Molecular Catalysis B, 103:100–105, DOI-Link
  • Volmer J., Neumann C., Bühler B. and Schmid A. (2014)
    Engineering of Pseudomonas taiwanensis VLB120 for constitutive solvent tolerance and increased specific styrene epoxidation activity.
    Applied and Environmental Microbiology, 80(20):6539-6548, DOI-Link
  • Willrodt C., David C., Cornelissen S., Bühler B., Julsing M. K. and Schmid A. (2014)
    Engineering the productivity of recombinant Escherichia coli for limonene formation from glycerol in minimal media.
    Biotechnology Journal, 9(8):1000–1012, DOI-Link
  • Churakova E.*, Tomaszewski B.*, Bühler K., Schmid A., Arends I. W. C. E and Hollmann F. (2014)
    Hydrophobic formic acid esters for cofactor regeneration in aqueous / organic two-liquid phase systems.
    Topics in Catalysis, 57(5):385-391, DOI-Link
    * These authors contributed equally to this work.
  • Lang K., Zierow J., Bühler K. and Schmid A. (2014)
    Metabolic engineering of Pseudomonas sp. VLB120 towards a platform biocatalyst for the production of isobutyric acid and other secondary metabolites.
    Microbial Cell Factories, 13:2, DOI-Link
  • Schrewe M., Julsing M. K., Lange K., Czarnotta E, Schmid A. and Bühler B. (2014)
    Reaction and catalyst engineering to exploit kinetically controlled whole-cell multistep biocatalysis for terminal FAME oxyfunctionalization.
    Biotechnology and Bioengineering, 111(9):1820-1830, DOI-Link
  • Tomaszewski B., Lloyd R., Warr A., Bühler K. and Schmid A. (2014)
    Regioselective biocatalytic aromatic hydroxylation in a gas-liquid multiphase tube-in-tube reactor.
    ChemCatChem, 6(9):2567–2576, DOI-Link
  • Halan B., Letzel T., Schmid A. and Bühler K. (2014)
    Scalability of a solid support membrane aerated biofilm reactor for the continuous synthesis of (S)-styrene oxide.
    Biotechnology Journal, 9(10):1339-1349, DOI-Link
  • Karande R.*, Halan B.*, Schmid A. and Bühler K. (2014)
    Segmented flow is controlling growth of catalytic biofilms in continuous multiphase microreactors.
    Biotechnology and Bioengineering, 111(9):1831-1840, DOI-Link
    * These authors contributed equally to this work.
  • Sudarsan S., Dethlefsen S., Blank L. M., Siemann-Herzberg M. and Schmid A. (2014)
    The functional structure of central carbon metabolism.
    Applied and Environmental Microbiology, 80(17):5292-5303 , DOI-Link
  • Ladkau N., Schmid A. and Bühler B. (2014)
    The microbial cell - functional unit for energy-dependent multistep biocatalysis.
    Current Opinion in Biotechnology, 30:178-189, DOI-Link
2013
  • Köhler K. A. K., Rückert C., Schatschneider S., Vorhölter F., Sczepanowski R., Blank L. M., Niehaus K., Goesmann A., Pühler A., Kalinowski J. and Schmid A. (2013)
    Complete genome sequence of Pseudomonas sp. strain VLB120 a solvent tolerant, styrene degrading bacterium, isolated from forest soil.
    Journal of Biotechnology, 168(4):729-730, DOI-Link
  • Schrewe M., Ladkau N., Bühler B. and Schmid A. (2013)
    Direct terminal alkylamino-functionalization via multistep biocatalysis in one recombinant whole-cell catalyst.
    Advanced Synthesis and Catalysis, 355(9):1693-1697, DOI-Link
  • Gross R., Bühler K. and Schmid A. (2013)
    Engineered catalytic biofilms for continuous large scale production of n-octanol and (S)-styrene oxide.
    Biotechnology and Bioengineering, 110(2):424–436, DOI-Link
  • Fritzsch F. S. O., Rosenthal K., Kampert A., Howitz S., Dusny C., Blank L. M. and Schmid A. (2013)
    Picoliter nDEP traps enable time-resolved contactless single bacterial cell analysis in controlled microenvironments.
    Lab on a Chip, 13(3):397-408, DOI-Link
  • Falcioni F., Blank L. M., Frick O., Karau A., Bühler B. and Schmid A. (2013)
    Proline availability regulates proline-4-hydroxylase synthesis and substrate uptake in proline-hydroxylating recombinant Escherichia coli.
    Applied and Environmental Microbiology, 79(9):3091-3100, DOI-Link
  • Jahn M., Seifert J., von Bergen M., Schmid A., Bühler B. and Müller S. (2013)
    Subpopulation-proteomics in prokaryotic populations.
    Current Opinion in Biotechnology, 24(1):79-87, DOI-Link
  • Kuhn D., Fritzsch F. S. O., Zhang X., Wendisch V. F., Blank L. M., Bühler B. and Schmid A. (2013)
    Subtoxic product levels limit the epoxidation capacity of recombinant E. coli by increasing microbial energy demands.
    Journal of Biotechnology, 163(2):194-203, DOI-Link, PubMed
  • Schrewe M.*, Julsing M. K.*, Bühler B. and Schmid A. (2013)
    Whole-cell biocatalysis for selective and productive C-O functional group introduction and modification.
    Chemical Society Reviews, 42(15):6346 - 6377, DOI-Link
    * These authors contributed equally to this work.
  • Cornelissen S., Julsing M. K., Volmer J., Riechert O., Schmid A. and Bühler B. (2013)
    Whole-cell-based CYP153A6-catalyzed (S)-limonene hydroxylation efficiency depends on host background and profits from monoterpene uptake via AlkL.
    Biotechnology and Bioengineering, 110(5):1282-1292, DOI-Link
2012
  • Halan B., Bühler K. and Schmid A. (2012)
    Biofilms as living catalysts in chemical synthesis.
    Trends in Biotechnology, 30(9):453-465, DOI-Link
  • Cornelissen S., Julsing M. K., Schmid A. and Bühler B. (2012)
    Comparison of microbial hosts and expression systems for mammalian CYP1A1 catalysis.
    Journal of Industrial Microbiology and Biotechnology, 39(2):275-287, DOI-Link
  • Ütkür F.Ö., Tran T.-T., Collins J., Brandenbusch C., Sadowski G., Schmid A. and Bühler B. (2012)
    Integrating organic-aqueous biocatalysis and product recovery using quinaldine 4-oxidase in living P. putida KT2440 (pKP1).
    Journal of Industrial Microbiology & Biotechnology, 39(7):1049-1059, DOI-Link
  • Dusny C., Fritzsch F. S. O., Frick O. and Schmid A. (2012)
    Isolated Microbial Single Cells and Resulting Micropopulations Grow Faster in Controlled Environments.
    Applied and Environmental Microbiology, 78(19):7132-7136, DOI-Link
  • Gernaey K. V., Baganz F., Franco-Lara E., Kensy F., Krühne U., Luebberstedt M., Marx U., Palmqvist E., Schmid A., Schubert F. and Mandenius C.-F. (2012)
    Monitoring and control of microbioreactors for applications in biotechnology: A review.
    Biotechnology Journal, 7:1308-1314, DOI-Link
  • Kuhn D., Bühler B. and Schmid A. (2012)
    Production host selection for asymmetric styrene epoxidation: Escherichia coli vs. solvent tolerant Pseudomonas.
    Journal of Industrial Microbiology and Biotechnology, 39(8):1125-1133, DOI-Link
  • Julsing M. K., Kuhn D., Schmid A. and Bühler B. (2012)
    Resting cells of recombinant E. coli show high epoxidation yields on energy source and high sensitivity to product inhibition.
    Biotechnology and Bioengineering, 109(5):1109-1119, DOI-Link
  • Blank L. M., Deshpande R., Schmid A. and Hayen H. (2012)
    Simultaneous analysis of carbon and nitrogen metabolism by ultra-high-resolution mass spectrometry applying 13C- and 15N-labeled substrates simultaneously.
    Analytical and Bioanalytical Chemistry, 403(8):2291-2305, DOI-Link
  • Fritzsch F. S. O.*, Dusny C.*, Frick O. and Schmid A. (2012)
    Single Cell Analysis in Biotechnology, Systems Biology, and Biocatalysis.
    Annual Review of Chemical and Biomolecular Engineering, 3:129-155, DOI-Link
    * These authors contributed equally to this work.
  • Braun A., Geier M., Bühler B., Schmid A., Mauersberger S. and Glieder A. (2012)
    Steroid biotransformations in biphasic systems with Yarrowia lipolytica expressing human liver cytochrome P450 genes.
    Microbial Cell Factories, 11:106, DOI-Link
  • Rühl J., Hein E. M., Hayen H., Schmid A. and Blank L. M. (2012)
    The glycerophospholipid inventory of Pseudomonas putida is conserved between strains and enables growth condition related alterations.
    Microbial Biotechnology, 5(1):45-58, DOI-Link, PubMed
  • Julsing M. K.*, Schrewe M.*, Cornelissen S., Hermann I., Schmid A. and Bühler B. (2012)
    The outer membrane protein AlkL boosts biocatalytic oxyfunctionalization of hydrophobic substrates in E. coli.
    Applied and Environmental Microbiology, 78(16):5724-5733, DOI-Link
    * These authors contributed equally to this work.
2011
  • Heyland J., Fu J., Blank L. M. and Schmid A. (2011)
    Carbon metabolism limits recombinant protein production in Pichia pastoris.
    Biotechnology and Bioengineering, 108(8):1942-1953, DOI-Link, PubMed
  • Cornelissen S., Liu S, Deshmukh A.T., Schmid A. and Bühler B. (2011)
    Cell physiology can determine the efficiency of cytochrome P450-catalyzed C-H-oxyfunctionalization.
    Journal of Industrial Microbiology and Biotechnology, 38:1359-1370, DOI-Link
  • Ladkau N., Hermann I., Bühler B. and Schmid A. (2011)
    Enzyme catalyzed laurolactam synthesis via intramolecular amide bond formation in aqueous solution.
    Advanced Synthesis and Catalysis, 353(13):2501-2510, DOI-Link
  • Ruinatscha R., Karande R., Bühler K. and Schmid A. (2011)
    Integrated one-pot enrichment and immobilization of styrene monooxygenase (StyA) using Sepabead EC-EA and EC-Q1A anion-exchange carriers.
    Molecules, 16(7):5975-5988, DOI-Link
  • Schrewe M., Magnusson A., Willrodt C., Bühler B. and Schmid A. (2011)
    Kinetic analysis of terminal and unactivated C-H bond oxyfunctionalization in fatty acid methyl esters by monooxygenase-based whole-cell biocatalysis.
    Advanced Synthesis and Catalysis, 353:3485 – 3495, DOI-Link
  • Karande R., Schmid A. and Bühler K. (2011)
    Miniaturizing Biocatalysis: Enzyme catalyzed reactions in an aqueous/organic segmented flow capillary microreactor.
    Advanced Synthesis and Catalysis, 353(13):2511-2521, DOI-Link
  • Fritzsch F. S. O., Kortmann H., Lonzynski J., Blank L. M. and Schmid A. (2011)
    Pressure resistant and reversible on-tube-sealing for microfluidics.
    Microfluidics and Nanofluidics, 10(3):679-684, DOI-Link
  • Heyland J., Blank L. M. and Schmid A. (2011)
    Quantification of metabolic limitations during recombinant protein production in Escherichia coli.
    Journal of Biotechnology, 155(2):178-184, DOI-Link, PubMed
  • Halan B., Schmid A. and Bühler K. (2011)
    Real time solvent tolerance analysis of Pseudomonas sp. strain VLB120ΔC catalytic biofilms.
    Applied and Enviromental Microbiology, 77(5):1563-1571, DOI-Link
  • Ütkür F.Ö., Gaykawad S., Bühler B. and Schmid A. (2011)
    Regioselective aromatic hydroxylation of quinaldine with water using quinaldine 4-oxidase in recombinant Pseudomonas putida.
    Journal of Industrial Microbiology and Biotechnology, 38(8):1067-1077, DOI-Link
  • Ebert B. E., Kurth F., Grund M., Blank L. M. and Schmid A. (2011)
    Response of P. putida KT2440 to increased NADH and ATP demand.
    Applied and Environmental Microbiology, 77(18):6597–6605, DOI-Link, PubMed
  • Kortmann H., Blank L. M. and Schmid A. (2011)
    Single cell analytics: an overview.
    Advances in Biochemical Engineering and Biotechnology, 124:99-122, DOI-Link, PubMed
2010
  • Gross R., Lang K., Bühler K. and Schmid A. (2010)
    Characterization of a biofilm membrane reactor and its prospects for fine chemical synthesis.
    Biotechnology and Bioengineering, 105(4):705-717, DOI-Link
  • Schmid A., Kortmann H., Dittrich P. and Blank L. M. (2010)
    Chemical and biological single cell analysis.
    Current Opinion in Biotechnology, 21(1):12-20, DOI-Link, PubMed
  • Brandenbusch C., Bühler B., Hoffmann P., Sadowski G. and Schmid A. (2010)
    Efficient phase separation and product recovery in organic-aqueous bioprocessing using supercritical carbon dioxide.
    Biotechnology and Bioengineering, 107(4):642-651, DOI-Link
  • Karande R., Schmid A. and Bühler K. (2010)
    Enzyme catalysis in an aqueous/organic segment flow microreactor: ways to stabilize enzyme activity.
    Langmuir, 26(11):9152-9159, DOI-Link
  • Gardossi L, Poulsen P. B., Ballesteros A., Hult K., Švedas V. K., Vasić-Rački Ð., Carrea G., Magnusson A., Schmid A., Wohlgemuth R. and Halling P. J. (2010)
    Guidelines for reporting of biocatalytic reactions.
    Trends in Biotechnology, 28(4):171-180, DOI-Link
  • Kuhn D., Kholiq A., Heinzle E., Bühler B. and Schmid A. (2010)
    Intensification and economic and ecological assessment of a biocatalytic oxyfunctionalization process.
    Green Chemistry, 12(5):815-827, DOI-Link
  • Heck T., Makam S., Lutz J., Blank L. M., Schmid A., Seebach Dieter, Kohler H.-P. E. and Geueke B. (2010)
    Kinetic analysis of L-carnosine formation by beta-aminopeptidases.
    Advanced Synthesis and Catalysis, 352(2-3):407-415, DOI-Link
  • Halan B., Schmid A. and Bühler K. (2010)
    Maximizing the productivity of catalytic biofilms on solid supports in membrane-aerated reactors.
    Biotechnology and Bioengineering, 106(4):516-527, DOI-Link
  • Holm A. K., Blank L. M., Oldiges M., Schmid A., Solem C., Jensen P. R. and Vemuri G. N. (2010)
    Metabolic and transcriptional response to cofactor perturbations in Escherichia coli.
    The Journal of Biological Chemistry, 285(23):17498-17506, DOI-Link, PubMed
  • Heyland J., Fu J., Blank L. M. and Schmid A. (2010)
    Quantitative physiology of Pichia pastoris during glucose-limited high cell-density fed-batch cultivation for recombinant protein production.
    Biotechnology and Bioengineering, 107(2):357-368, DOI-Link, PubMed
  • Heyland J., Antweiler N., Lutz J., Heck T., Geueke B., Kohler H.-P. E., Blank L. M. and Schmid A. (2010)
    Simple enzymatic procedure for carnosine synthesis: whole-cell biocatalysis and efficient biocatalyst recycling.
    Microbial Biotechnology, 3(1):74-83, DOI-Link, PubMed
  • Schmid A. and Blank L. M. (2010)
    Systems biology: Hypothesis-driven omics integration.
    Nature Chemical Biology (News & Views), 6:485-487, DOI-Link, PubMed
  • Kuhn D., Blank L. M., Schmid A. and Bühler B. (2010)
    Systems biotechnology - rational biocatalyst and bioprocess design.
    Engineering in Life Sciences, 10(5):384–397, DOI-Link
2009
  • Kortmann H., Blank L. M. and Schmid A. (2009)
    A rapid, reliable, and automatable interface for microfluidic devices.
    Lab-on-a-Chip, 9:1455 - 1460, DOI-Link, PubMed
  • Maddula Sasidhar, Blank L. M., Schmid A. and Baumbach J. I. (2009)
    Detection of volatile metabolites of Escherichia coli by multi capillary column coupled ion mobility spectrometry.
    Analytical and Bioanalytical Chemistry, 394(3):791-800, DOI-Link, PubMed
  • Hein E. M., Blank L. M., Heyland J., Baumbach J. I., Schmid A. and Hayen H. (2009)
    Glycerophospholipid profiling by HPLC/MS using exact mass measurements and MSn fragmentation experiments in parallel.
    Rapid Communications in Mass Spectrometry, 23(11):1636-1646, DOI-Link, PubMed
  • Wierckx N. J. P., Ruijssenaars H. J., de Winde J. H., Schmid A. and Blank L. M. (2009)
    Metabolic flux analysis of a phenol producing mutant of Pseudomonas putida S12: verification and complementation of hypotheses derived from transcriptomics.
    Journal of Biotechnology, 143(2):124–129, DOI-Link, PubMed
  • Rosche B., Li X. Z., Schmid A. and Bühler K. (2009)
    Microbial biofilms: A concept for industrial catalysis?
    TRENDS in Biotechnology, 27(11):636-643, DOI-Link
  • Ruinatscha R., Dusny C., Bühler K. and Schmid A. (2009)
    Productive asymmetric styrene epoxidation based on a next generation electroenzymatic methodology.
    Advanced Synthesis and Catalysis, 351:2505-2515, DOI-Link
  • Rühl J., Schmid A. and Blank L. M. (2009)
    Selected Pseudomonas putida strains able to grow in high concentrations of butanol.
    Applied and Environmental Microbiology, 75(13):4653-4656, DOI-Link, PubMed
  • Kortmann H., Blank L. M. and Schmid A. (2009)
    Single cell analysis reveals unexpected growth phenotype of S. cerevisiae.
    Cytometry: Part A, 75A(2):130-139, DOI-Link, PubMed
  • Kortmann H., Chasanis P., Blank L. M., Franzke J., Kenig E. Y. and Schmid A. (2009)
    The Envirostat - A new bioreactor concept.
    Lab-on-a-Chip, 9:576–585, DOI-Link, PubMed
  • Kortmann H., Kurth F., Blank L. M., Dittrich P. and Schmid A. (2009)
    Towards real time analysis of protein secretion from single cells.
    Lab-on-a-Chip, 9:3047-3049, DOI-Link, PubMed
2008
  • Tee K. L., Dmytrenko O., Otto K., Schmid A. and Schwaneberg U. (2008)
    A p-nitrothiophenolate screening system for the directed evolution of a two-component epoxygenase (StyAB).
    Journal of Molecular Catalysis B: Enzymatic, 50(2-4):121-127, DOI-Link
  • Kurth F., Schumann C. A., Blank L. M., Schmid A., Manz A. and Dittrich P. (2008)
    A bilayer microfluidic chip for diffusion-controlled activation of yeast species.
    Journal of Chromatography A, 1206(1):77-82, DOI-Link, PubMed
  • Julsing M. K., Cornelissen S., Bühler B. and Schmid A. (2008)
    Heme-iron oxygenases: powerful industrial biocatalysts?
    Current Opinion in Chemical Biology, 12(2):177-186, DOI-Link, PubMed
  • Blank L. M., Ebert B. E., Bühler B. and Schmid A. (2008)
    Metabolic capacity estimation of Escherichia coli as platform for redox biocatalysis: Constraint based modeling and experimental verification.
    Biotechnology and Bioengineering, 100(6):1050-1065, DOI-Link, PubMed
  • Blank L. M., Ionidis G., Ebert B. E., Bühler B. and Schmid A. (2008)
    Metabolic response of Pseudomonas putida during redox biocatalysis in the presence of a second octanol phase.
    FEBS Journal, 275(20):5173-5190, DOI-Link, PubMed
  • Bühler B., Park J. B., Blank L. M. and Schmid A. (2008)
    NADH availability limits asymmetric biocatalytic epoxidation in growing recombinant Escherichia coli.
    Applied and Environmental Microbiology, 74(5):1436-1446, DOI-Link, PubMed
  • Höllrigl V., Hollmann F., Kleeb A., Bühler K. and Schmid A. (2008)
    TADH, the thermostable alcohol dehydrogenase from Thermus sp. ATN1: A versatile new biocatalyst for organic synthesis.
    Applied Microbiology and Biotechnology, 81(2):263-273, DOI-Link, PubMed
  • Hollmann F. and Schmid A. (2008)
    Towards [Cp*Rh(bpy)(H2O)2+-promoted P450 catalysis: Direct regeneration of CytC.
    Journal of Inorganic Biochemistry, Epub, DOI-Link, PubMed
2007
  • Park J. B., Bühler B., Panke S., Witholt B. and Schmid A. (2007)
    Carbon metabolism and product inhibition determine the epoxidation efficiency of solvent tolerant Pseudomonas sp. strain VLB120ΔC.
    Biotechnology and Bioengineering, 98(6):1219-1229, DOI-Link, PubMed
  • Kortmann H., Blank L. M. and Schmid A. (2007)
    Cultivation of dielectrophoretically trapped single cells under optimal environmental conditions.
    Conference paper µTAS 2007, Conference Proceedings, (07.10.-11.10.2007):715-717
  • Höllrigl V., Otto K. and Schmid A. (2007)
    Electroenzymatic asymmetric reduction of rac-3-methylcyclohexanone to (1S,3S)-3-methylcyclohexanol in organic/aqueous media catalyzed by a thermophilic alcohol dehydrogenase.
    Advanced Synthesis & Catalysis, 349(8-9):1337-1340, DOI-Link
  • Gross R., Hauer B., Otto K. and Schmid A. (2007)
    Microbial biofilms: New catalysts for maximising productivty of long-term biotransformations.
    Biotechnology and Bioengineering, 98(6):1123-1134, DOI-Link, PubMed
2006
  • Bühler B., Straathof A. J. J., Witholt B. and Schmid A. (2006)
    Analysis of two-liquid-phase multistep biooxidation based on a process model: Indications for biological energy shortage.
    Organic Process Research and Development, 10(3):628-643, DOI-Link
  • Feenstra K. A., Hofstetter K., Bosch R., Schmid A., Commandeur J. M. N. and Vermeulen N. P. E. (2006)
    Enantioselective substrate binding in a monooxygenase protein model by molecular dynamics and docking.
    Biophysical Journal, 91(9):3026-3216, DOI-Link, PubMed
  • Hollmann F., Hofstetter K. and Schmid A. (2006)
    Non-enzymatic regeneration of nicotinamide and flavin cofactors for oxygenase catalysis.
    Trends in Biotechnology, 24(4):163-171, DOI-Link, PubMed
  • Meyer D., Bühler B. and Schmid A. (2006)
    Process and catalyst design objectives for specific redox biocatalysis.
    Advances in Applied Microbiology, 59:53-91, DOI-Link, PubMed
  • Ruinatscha R.*, Höllrigl V.*, Otto K. and Schmid A. (2006)
    Productivity of selective electroenzymatic reduction and oxidation reactions: Theoretical and practical considerations.
    Advanced Synthesis & Catalysis, 348(15):2015-2026, DOI-Link
    * These authors contributed equally to this work.
  • Yildrim S., Ruinatscha R., Gross R., Wohlgemuth R., Kohler H.-P. E., Witholt B. and Schmid A. (2006)
    Selective hydrolysis of the nitrile group of cis-dihydrodiols from aromatic nitriles.
    Journal of Molecular Catalysis B-Enzymatic, 38(2):76-83, DOI-Link
  • Park J. B.*, Bühler B.*, Habicher T., Hauer B., Panke S., Witholt B. and Schmid A. (2006)
    The efficiency of recombinant Escherichia coli as biocatalyst for stereospecific epoxidation.
    Biotechnology and Bioengineering, 95(3):501-512, DOI-Link, PubMed
    * These authors contributed equally to this work.
2005
  • Meyer D., Witholt B. and Schmid A. (2005)
    Suitability of recombinant Escherichia coli and Pseudomonas putida for selective biotransformation of m-nitrotoluene by xylene monooxygenase.
    Applied and Environmental Microbiology, 71(11):6624-6632, DOI-Link, PubMed
  • Hollmann F., Kleeb A., Otto K. and Schmid A. (2005)
    Coupled chemoenzymatic transfer hydrogenation catalysis for enantioselective reduction and oxidation reactions (Corrigendum in Tetrahedron-Asymmetry (2006), 17:867-868).
    Tetrahedron-Asymmetry, 16(21):3512-3519, DOI-Link
  • Hollmann F., Hofstetter K., Habicher T., Hauer B. and Schmid A. (2005)
    Direct electrochemical regeneration of monooxygenase subunits for biocatalytic asymmetric epoxidation.
    Journal of the American Chemical Society, 127(18):6540-6541, DOI-Link, PubMed
  • Unversucht S., Hollmann F., Schmid A. and van Pée K.-H. (2005)
    FADH2-dependence of tryptophan 7-halogenase.
    Advanced Synthesis & Catalysis, 347(7-8):1163-1167, DOI-Link
  • Neumann G., Kabelitz N., Zehnsdorf A., Miltner A., Lippold H., Meyer D., Schmid A. and Heipieper H. J. (2005)
    Prediction of the adaptability of Pseudomonas putida DOT-T1E to a second phase of a solvent for economically sound two-phase biotransformations.
    Applied and Environmental Microbiology, 71(11):6606-6612, DOI-Link, PubMed
  • Yildrim S., Franko T. T., Wohlgemuth R., Kohler H.-P. E., Witholt B. and Schmid A. (2005)
    Recombinant chlorobenzene dioxygenase from Pseudomonas sp. P51: A biocatalyst for specific oxidation of aromatic nitriles.
    Advanced Synthesis & Catalysis, 347(7-8):1060-1072, DOI-Link
2004
  • Yildrim S., Zezula J., Hudlicky T., Witholt B. and Schmid A. (2004)
    Asymmetric dihydroxylation of cinnamonitrile to trans-3-[(5S,6R)-5,6-dihydroxy- cyclohexa-1,3-dienyl]-acrylonitrile using chlorobenzene dioxygenase in Escherichia coli (pTEZ30).
    Advanced Synthesis & Catalysis, 346(8):933-942, DOI-Link
  • Otto K., Hofstetter K., Röthlisberger M., Witholt B. and Schmid A. (2004)
    Biochemical characterization of StyAB from Pseudomonas sp. strain VLB120 as a two-component non-heme flavin-diffusible styrene monooxigenase.
    Journal of Bacteriology, 186(16):5292-5302, DOI-Link, PubMed
  • Lutz J., Hollmann F., Ho T.-V., Schnyder A., Fish R. H. and Schmid A. (2004)
    Bioorganometallic chemistry: Biocatalytic oxidation reactions with biomimetic NAD+/NADH co-factors and [Cp*Rh(bpy)H]+ for selective organic synthesis.
    Journal of Organometallic Chemistry, 689(25):4783-4790, DOI-Link
  • Rojas A., Duque E., Schmid A., Hurtado A., Ramos J. L. and Segura A. (2004)
    Biotransformation in double-phase systems: Physiological responses of Pseudomonas putida DOT-T1E to a double phase made of aliphatic alcohols and biosynthesis of substituted catechols.
    Applied and Environmental Microbiology, 70(6):3637-3643, DOI-Link, PubMed
  • Hofstetter K., Lutz J., Lang I., Witholt B. and Schmid A. (2004)
    Coupling biocatalytic asymmetric epoxidation and NADH regeneration in organic-aqueous emulsions.
    Angewandte Chemie International Edition, 43(16):2163-2166, DOI-Link, PubMed
  • Hollmann F. and Schmid A. (2004)
    Electrochemical regeneration of oxidoreductases for cell-free biocatalytic redox reactions.
    Biocatalysis and Biotransformation, 22(2):63-88, DOI-Link
  • Bühler B. and Schmid A. (2004)
    Process implementation aspects for biocatalytic hydrocarbon oxyfunctionalisation.
    Journal of Biotechnology, 113(1-3):183-210, DOI-Link, PubMed
2003
  • Bühler B., Bollhalder I., Hauer B., Witholt B. and Schmid A. (2003)
    Chemical biotechnology for the specific oxyfunctionalization of hydrocarbons an a technical scale.
    Biotechnology and Bioengineering, 82(7):833-842, DOI-Link, PubMed
  • Meyer A., Tanner D., Schmid A., Sargent D. F., Kohler H.-P. E. and Witholt B. (2003)
    Crystallization and preliminary X-ray analysis of native selenomethionine 2-hydroxybiphenyl 3-monooxygenase.
    Acta Crystallographica Section D - Biological Crystallography, 59(4):741-743, DOI-Link, PubMed
  • van Beilen J. B., Duetz W. A., Schmid A. and Witholt B. (2003)
    Issues relevant for the practical application of oxygenases.
    Trends in Biotechnology, 21(4):170-177, DOI-Link
  • Hollmann F., Lin P.-C., Witholt B. and Schmid A. (2003)
    Stereospecific biocatalytic epoxidation: The first example of direct regeneration of a FAD-dependent monooxygenase for catalysis.
    Journal of the American Chemical Society, 125(27):8209-8217, DOI-Link, PubMed
  • Meyer A., Held M., Schmid A., Kohler H.-P. E. and Witholt B. (2003)
    Synthesis of 3-tert-butylcatechol by an engineered monooxygenase.
    Biotechnology and Bioengineering, 81(5):518-524, DOI-Link, PubMed
  • Bühler B., Bollhalder I., Hauer B., Witholt B. and Schmid A. (2003)
    Use of the two-liquid phase concept to exploit kinetically controlled multistep biocatalysis.
    Biotechnology and Bioengineering, 81(6):683-694, DOI-Link, PubMed
2002
  • Parales R. E., Bruce N. C., Schmid A. and Wackett L. P. (2002)
    Biodegradation, biotransformation and biocatalysis (b3).
    Applied and Environmental Microbiology, 68(10):4699-4709, DOI-Link, PubMed
  • Meyer A., Schmid A., Held M., Westphal A. H., Röthlisberger M., Kohler H.-P. E., van Berkel W. J. H. and Witholt B. (2002)
    Changing the substrate reactivity of 2-hydroxybiphenyl 3-monooxygenase from Pseudomonas azelaica HBP1 by directed evolution.
    Journal of Biological Chemistry, 277(7):5575-5582, DOI-Link, PubMed
  • Bühler B., Witholt B., Hauer B. and Schmid A. (2002)
    Characterization and application of xylene monooxygenase for multistep biocatalysis.
    Applied and Environmental Microbiology, 68(2):560-568, DOI-Link, PubMed
  • Meyer A., Würsten M., Schmid A., Kohler H.-P. E. and Witholt B. (2002)
    Hydroxylation of indole by laboratory-evolved 2-hydroxybiphenyl 3-monooxygenase.
    Journal of Biological Chemistry, 277(37):34161-34167, DOI-Link, PubMed
  • Li Z., van Beilen J. B., Duetz W. A., Schmid A., de Raadt A., Griengl H. and Witholt B. (2002)
    Oxidative biotransformations using oxygenases.
    Current Opinion in Chemical Biology, 6:136-144, DOI-Link
  • Panke S., Held M., Wubbolts M. G., Witholt B. and Schmid A. (2002)
    Pilot-scale production of S-styrene oxide from styrene by recombinant Escherichia coli synthesizing styrene monooxygenase.
    Biotechnology and Bioengineering, 80(1):33-41, DOI-Link, PubMed
  • Lutz J., Mozhaev V. V., Khmelnitsky Y. L., Witholt B. and Schmid A. (2002)
    Preperative application of 2-hydroxybiphenyl 3-monooxygenase with enzymatic cofactor regeneration in organic-aqueous reaction media.
    Journal of Molecular Catalysis B-Enzymatic, 19-20:177-187, DOI-Link
  • Straathof A. J. J., Panke S. and Schmid A. (2002)
    The production of fine chemicals by biotransformations.
    Current Opinion in Biotechnology, 13(6):548-556, DOI-Link, PubMed
  • Schmid A., Hollmann F., Park J. B. and Bühler B. (2002)
    The use of enzymes in the chemical industry in Europe.
    Current Opinion in Biotechnology, 13(4):359-366, DOI-Link, PubMed
  • Hollmann F., Witholt B. and Schmid A. (2002)
    [Cp*Rh(bpy)(H2O)]2+: A versatile tool for efficient and non enzymatic regeneration of nicotinamide and flavin coenzymes.
    Journal of Molecular Catalysis B-Enzymatic, 19-20:167-176, DOI-Link
2001
  • Schmid A., Dordick J. S., Hauer B., Kiener A., Wubbolts M. G. and Witholt B. (2001)
    Industrial biocatalysis today and tomorrow.
    Nature, 409(6817):258-268, DOI-Link, PubMed
  • Schmid A., Hofstetter K., Feiten H.-J., Hollmann F. and Witholt B. (2001)
    Integrated biocatalytic synthesis on gram scale: The highly enantioselective preparation of chiral oxiranes with styrene monooxygenase.
    Advanced Synthesis & Catalysis, 343(6-7):732-737, DOI-Link
  • Schmid A., Vereyken I., Held M. and Witholt B. (2001)
    Preperative regio- and chemoselective functionalization of hydrocarbons catalyzed by cell free preparations of 2-hydroxybiphenyl 3-monooxygenase.
    Journal of Molecular Catalysis B-Enzymatic, 11(4):455-462, DOI-Link
  • Hollmann F., Schmid A. and Steckhan E. (2001)
    The first synthetic application of a monooxygenase employing indirect electrochemical NADH regeneration.
    Angewandte Chemie - International Edition in English, 40(1):169-171, DOI-Link, PubMed
  • Jaspers M. C. M., Schmid A., Sturme M. J. H., Goslings D. A. M., Kohler H.-P. E. and van der Meer J. R. (2001)
    Transcriptional organization and dynamic expression of the hbpCAD genes, which encode the first three enzymes for 2-hydroxybiphenyl degradation in Pseudomonas azelaica HBP1.
    Journal of Bacteriology, 183(1):270-279, DOI-Link, PubMed
2000
  • Jaspers M. C. M., Suske W. A., Schmid A., Goslings D. A. M., Kohler H.-P. E. and van der Meer J. R. (2000)
    HbpR, a new member of the XylR/DmpR subclass within the NtrC family of bacterial transcriptional activators, regulates the expression of 2-hydroxybiphenyl metabolism in Pseudomonas azelaica.
    Journal of Bacteriology, 182(2):405-417, PubMed
  • Panke S., Wubbolts M. G., Schmid A. and Witholt B. (2000)
    Production of enantiopure styrene oxide by recombinant Escherichia coli synthesizing a two-component styrene monooxygenase.
    Biotechnology and Bioengineering, 69(1):91-100, DOI-Link, PubMed
  • Bühler B., Schmid A., Hauer B. and Witholt B. (2000)
    Xylene monooxygenase catalizes the multistep oxygenation of toluene and pseudocumene to corresponding alcohols, aldehydes, and acids in Escherichia coli JM101.
    Journal of Biological Chemistry, 275(14):10085-100092, PubMed
1999
  • Held M., Schmid A., Kohler H.-P. E., Suske W. A., Witholt B. and Wubbolts M. G. (1999)
    An integrated process for the production of toxic catechols from toxic phenols based on a designer biocatalyst.
    Biotechnology and Bioengineering, 62(6):641-648, DOI-Link, PubMed
  • Held M., Panke S., Kohler H.-P. E., Feiten H.-J., Schmid A., Schmid A., Wubbolts M. G. and Witholt B. (1999)
    Solid phase extraction for biocatalytic production of toxic compounds.
    Bioworld, 5:2-9
1998
  • Schmid A., Kohler H.-P. E. and Engesser K.-H. (1998)
    Escherichia coli JM101 pHBP461, a recombinant biocatalyst for the regioselective monohydroxylation of ortho-substituted phenols to their corresponding 3-substituted catechols.
    Journal of Molecular Catalysis B-Enzymatic, 5(1-4):311-316, DOI-Link
  • Held M., Suske W. A., Schmid A., Engesser K.-H., Kohler H.-P. E., Witholt B. and Wubbolts M. G. (1998)
    Preparative scale production of 3-substituted catechols using a novel monooxygenase from Pseudomonas azelaica.
    Journal of Molecular Catalysis B-Enzymatic, 5(1-4):87-93, DOI-Link
  • Panke S., Witholt B., Schmid A. and Wubbolts M. G. (1998)
    Towards a biocatalyst for S-styrene oxide production: characterization of the styrene degradation pathway of Pseudomonas sp. VLB120.
    Applied and Environmental Microbiology, 64(6):2032-2043, PubMed
1997
  • Schmid A., Rothe B., Altenbucher J., Ludwig W. and Engesser K.-H. (1997)
    Characterisation of three distinct extradiol dioxygenases involved in mineralization of dibenzofuran by Terrabacter sp. strain DPO360.
    Journal of Bacteriology, 179(1):53-62, PubMed
  • Suske W. A., Held M., Schmid A., Fleischmann T., Wubbolts M. G. and Kohler H.-P. E. (1997)
    Purification and characterization of 2-hydroxybiphenyl 3-monooxygenase, a novel NADH-dependent, FAD-containing aromatic hydroxylase from Pseudomonas azelaica HBP1.
    Journal of Biological Chemistry, 272(39):24257-24265, DOI-Link, PubMed
1996
  • Suske W. A., Kohler H.-P. E., Held M., Wubbolts M. G. and Schmid A. (1996)
    2-Hydroxybiphenyl 3-monooxygenase, a novel member of the group of FAD-containing aromatic hydroxylases.
    Flavins and Flavoproteins 1996, (Proceedings):383-386, Direct-Link
1994
  • Engesser K.-H., Dohms C. and Schmid A. (1994)
    Microbial degradation of model compounds of coal and production of metabolites with potential commercial value.
    Fuel Processing Technology, 40(2-3):217-226, DOI-Link
1993
  • Kohler H.-P. E., Schmid A. and van der Maarel M. (1993)
    Metabolism of 2,2’-dihydroxybiphenyl by Pseudomonas sp. strain HBP1: Production and consumption of 2,2’,3-trihydroxybiphenyl.
    Journal of Bacteriology, 175(6):1621-1628, PubMed
Books & Bookchapters
2012
  • Bühler K. and Schmid A. (2012)
    Catalytic biofilms: a powerful concept for future bioprocesses.
    in Lear, G. and Lewis, G. Microbial biofilms: Current research and applications.
    Caister Academic Press, Norfolk, UK:193 - 222, ISBN: 978-1-904455-96-7
  • Ütkür F.Ö., Collins J., Brandenbusch C., Sadowski G., Schmid A. and Bühler B. (2012)
    Regioselective Aromatic Hydroxylation of Quinaldine Using Living Pseudomonas putida Cells Containing Quinaldine 4-oxidase.
    in John Whitthal and Peter Sutton Practical Methods in Biocatalysis and Biotransformations 2.
    John Wiley & Sons Ltd, Chichester, UK:153-157, ISBN: 978-1-119-99139-7
2011
  • Brandenbusch C., Bühler B., Sadowski G. and Schmid A. (2011)
    Biokatalytische Epoxidierung von Styrol zu enantiomerenreinem (S)-Styroloxid.
    in Chmiel H. Bioprozesstechnik.
    Spektrum Akademischer Verlag, Heidelberg, Germany:486-488, ISBN: 978-3-8274-2476-1, Amazon-Link
2009
  • Bühler K. and Schmid A. (2009)
    Biopetrochemicals via biocatalysis by hydrocarbon microbes and their enzymes.
    in Kenneth Timmis Handbook of Hydrocarbon and Lipid Microbiology.
    Springer, Berlin, Germany, Vol. 1, ISBN: 3540775889
  • Bühler B., Blank L. M., Ebert B. E., Bühler K. and Schmid A. (2009)
    Energy and cofactor issues in fermentation and oxyfunctionalisation processes.
    in Smolke C. D. The metabolic pathway engineering handbook.
    CRC Press, Boca Raton, Florida, USA, Vol. 2:21 1-32, ISBN: 978-1-4200-7765-0
  • Bühler K. and Schmid A. (2009)
    Synthesis of enantiopure (S)-styrene oxide by selective oxidation of styrene by recombinant E. coli.
    in John Witthall and Peter Sutton Practical Methods in Biocatalysis and Biotransformations.
    John Wiley & Sons Ltd, Chichester, UK:385-390, ISBN: 978-0-470-51927-1, Wiley-Link
2008
  • Eissen M., Geisler G., Bühler B., Fischer C., Hungerbuehler K., Schmid A. and Carreira E. M. (2008)
    Mass Balances and Life Cycle Assessment.
    in Lapkin A. and Constable D. Green Chemistry Metrics: Measuring and Monitoring Sustainable Processes.
    John Wiley & Sons Ltd, Chichester, West Sussex, UK:200-227
2005
  • Bühler B. and Schmid A. (2005)
    Selective enzymatic hydroxylations.
    in Dyker G. Handbook of C-H transformations.
    Wiley-VCH, Weinheim, Germany, Vol. 2:516-529
2003
  • Lenke H. and Schmid A. (2003)
    Biotransformations.
    in Doelle H. Encyclopedia of life support systems.
    EOLSS Publishers Co. Ltd., Oxford, UK
2002
  • Hollmann F., Bühler B. and Schmid A. (2002)
    Oxidation of alcohols, phenols, aldehydes, acids and C-N bonds.
    in Drauz K. and Waldmann H. Enzyme catalysis in organic synthesis.
    Wiley-VCH, Weinheim, Germany, Vol. III:1108-1202, 1245-1261, ISBN: 3-527-29949-1
1997
  • Schmid A. (1997)
    PhD Thesis: Der Metabolismus von 2-Hydroxybiphenyl-Verbindungen in Pseudomonas azeleica HBP1: Grundlegende Untersuchungen und ihre biotechnologische Anwendung.
    Universitiy of Stuttgart
Patent applications
2012
  • Fritzsch F. S. O., Howitz S., Blank L. M. and Schmid A. (2012)
    Method for the separation of polarisable bioparticles.
    PCT/EP2011/057724, filed
2011
  • Schmid A., Bühler B., Ladkau N. and Hermann I. (2011)
    Method for omega-aminocarboxylic acid condensation.
    Europe, WO/2012/156151 / PCT/EP2012/056251 / priority: 11004029.2 16.05.2011 EP
  • Schmid A., Karande R. and Bühler K. (2011)
    Segmented Flow Biofilm Reactor.
    WO/2012/152337 PCT/EP2011/057724, filed
2010
  • Pötter M., Schmid A., Bühler B., Hennemann H.-G., Julsing M. K., Schaffer S., Haas T., Schrewe M., Cornelissen S., Roos M. and Häger H. (2010)
    Biocatalytic oxidation process with alkL-gene product.
    WO 2011/131420 / PCT/EP2011/053834 / priority: 10 2010 015 807.0 20.04.2010 DE
2007
  • Sadowski G., Schmid A., Brandenbusch C., Bühler B. and Görnert M. (2007)
    Method for processing coalescence-inhibited emulsions from whole-cell biotransformations with compressed or supercritical gases.
    WO/2009/012754 / EP2170481 / DE 10 2007 034 258.8 / US 8,431,358 B2
  • Karau A., Sieber V., Haas T., Häger H., Grammann K., Bühler B., Blank L. M. and Schmid A. (2007)
    omega-amino carboxylic acids, omega-amino carboxylic acid esters, or recombinant cells which produce lactams thereof.
    WO/2009/077461 / PCT/EP2008/067447 / priority: 102007060705.0 17.12.2007 DE
2002
  • Schmid A., Hollmann F. and Witholt B. (2002)
    Selective functionalization of hydrocarbons with isolated oxygenases and mediator based regeneration.
    WO/2004/003210
2001
  • Schmid A., Hauer B., Bühler B. and Witholt B. (2001)
    Method for the oxidation of aromatic compunds.
    WO/2002/081718 / PCT/EP2002/003803 / priority: 101 17 359.8 06.04.2001 DE
2000
  • Schmid A., Hollmann F. and Steckhan E. (2000)
    Method comprising the indirect electrochemical regeneration of NAD(P)H.
    WO 01/088172
1999
  • Schmid A., Panke S., Feiten H.-J. and Witholt B. (1999)
    Biocatalytic epoxidation of vinylaromatic compounds.
    EP 99 203 857.0
  • Schmid A., Bühler B., Hauer B. and Witholt B. (1999)
    Microbiological method for producing aromatic aldehydes and/or carboxylic acids.
    WO/2001/031047 / PCT/EP2000/010552 / priority: 199 51 768.1 27.10.1999 DE
Oral Presentations
2010
  • Schmid A., Karande R., Lutz J. and Bühler K. (2010)
    Application of CLEAS in a segmented flow capillary microreactor system.
    CBCS, 18. - 19. March 2010, Graz, Austria
  • Schmid A., Karande R., Lutz J. and Bühler K. (2010)
    Application of CLEAs in a Segmented Flow Capillary Microreactor System.
    CBCS conference on Biocatalysis for Chemical Synthesis, 18. - 19. March 2010, Graz, Austria
2009
  • Schmid A., Kortmann H. and Blank L. M. (2009)
    Single Cell Analysis in Biotechnology.
    ACHEMA, 10. May 2009, Frankfurt, Germany
2008
  • Schmid A., Kortmann H. and Blank L. M. (2008)
    Single Cell Analysis in Industrial Biotechnology.
    4th International Conference on Analysis of Microbial Cells at the Single Cell Level, 22. - 24. May 2008, Bad Schandau, Germany
  • Schmid A., Kortmann H. and Blank L. M. (2008)
    A System Approach to Single Cell Biochemistry.
    MSB 2008, 9. - 13. March 2008, Berlin, Germany
Posters
2015
  • Willrodt C., Hoschek A., Julsing M. K. and Schmid A. (2015)
    Mixed-culture resting cell fermentation enables production of oxygenated monoterpenoids.
    Bioflavour 2015 - International Conference on Flavour and Fragrance Biotechnology, 9. - 11. September 2015, Frankfurt, Germany
  • Grund M., Frick O., Bühler B. and Schmid A. (2015)
    Towards quantitative physiology in cyanobacteria by isotopically instationary 13C-metabolic flux analysis .
    DECHEMA Summer School Quantitative Biology 2015, 20. - 24. July 2015, Berlin, Germany
  • Rosenthal K., Dusny C. and Schmid A. (2015)
    The next-generation Envirostat: An inert microfluidic bioreactor for the isolation and analysis of a single microbial cell in defined environments.
    6th International Conference on Analysis of Microbial Cells at the Single Cell Level, 19-22 July 2015, Retz, Austria
  • Willrodt C., Hoschek A., Julsing M. K. and Schmid A. (2015)
    Synthetic biology for synthetic chemistry - Enabling Cascade Reactions by Modular Two-Strain Fermentations.
    Gordon Research Conference on Synthetic Biology, 28. June - 3. July 2015, Newry, ME, USA
  • Oehling V., Frick O., Klaassen P. and Schmid A. (2015)
    L-arabinose utilization by industrially relevant Saccharomyces cerevisiae.
    5th BE-Basic Symposium, 31. March. - 1. April 2015, Noordwijk, the Netherlands
2014
  • Ladkau N., Schrewe M., Schmid A. and Bühler B. (2014)
    Three-step sequential whole-cell biocatalysis for the technical scale production of 12-aminododecanoic acid methyl ester from renewables.
    3rd Multistep Enzyme Catalyzed Processes Congress (MECP14), 7. - 10. April 2014, Madrid, Spain
  • Grund M., Frick O., Bühler B. and Schmid A. (2014)
    Metabolic Engineering of Cyanobacteria as Efficient Industrial Biocatalysts.
    DECHEMA Summer School Biotransformations 2014, 24. - 27. August 2014, Bad Herrenalb, Germany
  • Rosenthal K., Dusny C., Oehling V., Frick O. and Schmid A. (2014)
    Analysis of a single-cell: Imprisoned, but feeling well.
    5th annual CLIB-graduate cluster retreat, 12. – 14. February 2014, Lünen, Germany
  • David C., Grund M., Bühler B., Bühler K. and Schmid A. (2014)
    Applied Biocatalysis & Bio-Artificial Photosynthesis.
    POF III Evaluation Meeting, February 4th, 2014, Berlin, Germany
  • Dusny C., Fritzsch F. S. O., Rosenthal K. and Schmid A. (2014)
    Quantitative single cell analysis reveals faster growth of isolated microbes in controlled microenvironments in comparison to populations (Best poster award).
    SysBio2014 Advanced Lecture Course on Systems Biology, 02. – 08. March 2014, Innsbruck, Austria
  • Rosenthal K., Dusny C., Oehling V., Frick O. and Schmid A. (2014)
    The Envirostat 3.0: Microfluidic chip development for sampling of metabolites secreted by a single cell.
    3rd BioProScale Symposium, 02. - 04. March 2014, Berlin, Germany
2013
  • Brandenbusch C., Glonke S., Collins J., Bühler B., Schmid A. and Sadowski G. (2013)
    Stable emulsions in biphasic whole-cell biocatalysis: The mechanism of scCO2-assisted phase separation.
    ProcessNet Jahrestagung der Fachgemeinschaft Fluiddynamik und Trenntechnik, 25. - 27. September 2013, Würzburg, Germany
  • Willrodt C., David C., Julsing M. K., Bühler B. and Schmid A. (2013)
    Biocatalyst and process development for fermentative synthesis of monoterpene-derived natural product.
    1st European Conference on Natural Products, September 22-25 2013, Frankfurt am Main, Germany
  • Willrodt C., David C., Julsing M. K., Bühler B. and Schmid A. (2013)
    Biocatalyst and process development for the fermentative synthesis of monoterpene-derived natural product.
    Biotrans 2013, July 21st - July 25th 2013, Manchester, United Kingdom
  • Lange K., Schütz V, Czepnik M, Quentmeier A, Kayser O., Maaß M., Julsing M. K. and Schmid A. (2013)
    Biotransformation of cannabigerolic acid (CBGA) to tetrahydrocannabinolic acid (THCA) using cell free THCA synthase from Cannabis sativa.
    Biotrans 2013, July 21st - July 25th 2013, Manchester, United Kingdom
  • Schrewe M., Ladkau N., Lange K., Czarnotta E, Julsing M. K., Bühler B. and Schmid A. (2013)
    Reaction and catalyst engineering for whole-cell-based multistep ω-functionalization of renewables: Sustainable and efficient production of bifunctional building blocks for polymer syntheses.
    Biotrans 2013, 21. - 25. July 2013, Manchester, UK
  • Ladkau N., Schrewe M., Aßmann M., Klassen G., Bühler B. and Schmid A. (2013)
    Strain engineering for the omega-aminofunctionalization of dodecanoic acid methyl ester via multistep biocatalysis.
    Biotrans 2013, 21. - 25. July 2013, Manchester, UK
  • Lindmeyer M., Schmid A. and Bühler B. (2013)
    Variability analysis of different Pseudomonas strains during oxidative whole‐cell biocatalysis.
    Biotrans 2013, 21. - 25. July 2013, Manchester, UK
  • Falcioni F., Theodosiou E., Frick O., Schmid A. and Bühler B. (2013)
    Whole-cell biocatalysis for the conversion of L-proline to trans-4-hydroxy-L-proline with high specificity, yield, and productivity.
    Biotrans 2013, 21. - 25. July 2013, Manchester, UK
  • Lange K., Julsing M. K., Bühler B. and Schmid A. (2013)
    Biocatalyst design for the production of cannabinoids.
    CLIB Retreat, February 13, 2013, Lünen, Germany
  • Rosenthal K., Fritzsch F. S. O., Dusny C., Oehling V., Frick O. and Schmid A. (2013)
    The Way for Single Cell Analysis: Pick the right, hold it tight, - then do a sight, if it’s bright.
    4th annual CLIB-graduate cluster retreat, 13. – 15. February 2013, Lünen, Germany
  • Oehling V., Fritzsch F. S. O., Dusny C., Rosenthal K., Kortmann H., Frick O. and Schmid A. (2013)
    Single cell analysis of ethanol producing Saccharomyces cerevisiae.
    3rd BE-Basic Symposium, 5. - 7. February 2013, Noordwijkerhout, The Netherlands
  • Willrodt C., David C., Julsing M. K., Bühler B. and Schmid A. (2013)
    Preparation of monoterpenes from cheap and renewable resources.
    Tag der Chemie, TU Dortmund, February 1st, 2013, Dortmund, Germany
2012
  • Theodosiou E., Frick O., Bühler B. and Schmid A. (2012)
    Metabolic engineering of E.coli for the production of trans-4-hydroxy-L-proline.
    Metabolic Engineering IX, 3. - 7. June 2012, Biarritz, France
  • Volmer J., Neumann C., Schmid A. and Bühler B. (2012)
    Engineering Pseudomonas sp. strain VLB120 for redox biocatalysis with toxic reactants (Poster prize!).
    ESBES - 9th European Symposium on Biochemical Engineering Science, 23. - 26. September 2012, Istanbul, Turkey
  • Volmer J., Neumann C., Schmid A. and Bühler B. (2012)
    Towards a stable solvent tolerant phenotype of Pseudomonas sp. strain VLB120 for redox biocatalysis with toxic reactants.
    3rd annual CLIB-graduate cluster retreat, 22. - 24. February 2012, Bergisch-Gladbach, Germany
  • Dusny C., Fritzsch F. S. O., Rosenthal K., Frick O. and Schmid A. (2012)
    Quantitative physiology with isolated single cells and micropopulations in controlled microenvironments employing a picoliter bioreactor.
    The 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS), 28. October – 1. November 2012, Okinawa, Japan
  • Lindmeyer M., Schmid A. and Bühler B. (2012)
    The catalytic efficiency and expression of oxygenases in Pseudomonas.
    Biotrends 2012, 29. - 30. November 2012, Dortmund, Germany
  • Lang K., Schmid A. and Bühler K. (2012)
    Strain engineering towards an isobutyric acid and isobutanol producing catalytic biofilm.
    ESBES, 23. - 26. September 2012, Istanbul, Turkey
  • Rosenthal K., Fritzsch F. S. O., Dusny C., Oehling V., Frick O. and Schmid A. (2012)
    Fluoreszenz gestützte Analytik von Mikroorganismen im mikrofluidischen Einzelzellreaktor.
    ProcessNet-Jahrestagung, 10. - 13. September 2012, Karlsruhe, Germany
  • Lindmeyer M., Schmid A. and Bühler B. (2012)
    The catalytic efficiency and expression of oxygenases in Pseudomonas.
    ProcessNet-Jahrestagung 2012, 10. - 13. September 2012, Karlsruhe, Germany
  • Lange K., Hoschek A., Bühler B., Julsing M. K. and Schmid A. (2012)
    Functional expression of the THCA synthase from Cannabis sativa in E. coli.
    Biocat 2012, August 31st - September 4th 2012, Hamburg, Germany
  • Willrodt C., Julsing M. K., Bühler B. and Schmid A. (2012)
    Monoterpenoid production in metabolically engineered Escherichia coli.
    Biocat 2012, August 31st - September 4th 2012, Hamburg, Germany
  • Tomaszewski B., Schmid A., Hollmann F. and Bühler K. (2012)
    FDH coupled regeneration in low water media.
    GRC Biocatalysis, 8. - 13. July 2012, Smithfield, RI, USA
  • Ladkau N., Schrewe M., Julsing M. K., Bühler B. and Schmid A. (2012)
    Specific terminal oxy- and aminofunctionalization of dodecanoic acid methyl ester coupled in a single whole-cell catalyst.
    Gordon Research Conference Biocatalysis, 8. - 13. July 2012, Smithfield, RI, USA
  • Julsing M. K., Schrewe M., Cornelissen S., Schmid A. and Bühler B. (2012)
    The outer membrane protein AlkL: a tool for the microbial biotransformation of hydrophobic substrates.
    Gordon Research Conference Biocatalysis, 8. - 13. July 2012, Smithfield, RI, USA
  • Rensmann L., Maaß M., Teubner N.C., Bühler B., Julsing M. K. and Schmid A. (2012)
    Enzyme titer and specific activity of recombinant human CYP450 1A1 and 2D6 in function of cell physiology in a whole-cell set-up.
    11th International symposium on cytochrome P450. Biodiversity and Biotechnology., 22. - 26. June 2012, Turin, Italy, http://p450-torino.it/
  • Lang K., Schmid A. and Bühler K. (2012)
    Debottlenecking Pseudomonas sp. strain VLB120 for isobutanol synthesis.
    3rd annual CLIB-graduate cluster retreat, 22. - 24. February 2012, Bergisch-Gladbach, Germany
  • Julsing M. K., Kuhn D., Schmid A. and Bühler B. (2012)
    Resting cells of recombinant E. coli show high epoxidation yields on energy source and high sensitivity to product inhibition.
    Catalyzing Bio-Economy - Biocatalysts for Industrial Biotechnology, Annual meeting of the DECHEMA-VAAM-Section Biotransformations, 24. - 25. April 2012, Frankfurt am Main, Germany
  • Schmutzler K., Volmer J., Halan B., Bühler B., Bühler K. and Schmid A. (2012)
    Solvent tolerance in Pseudomonas sp. strain VLB120 - biofilms vs planktonic cells.
    VAAM Jahrestreffen, 18. - 21. March 2012, Tübingen, Germany
  • Rosenthal K., Fritzsch F. S. O., Dusny C., Frick O., Blank L. M. and Schmid A. (2012)
    An Overview: Microbioreactors and Analytics for Systems biology on Single Cell Level.
    2nd BioProScale Symposium, 14. - 16. March 2012, Berlin, Germany
  • Fritzsch F. S. O., Oehling V., Rosenthal K., Dusny C., Kampert A., Kortmann H., Frick O., Blank L. M. and Schmid A. (2012)
    Contactless single cell analysis of industrial relevant bacteria in controlled microenvironments.
    2nd BioProScale Symposium, 14. - 16. March 2012, Berlin, Germany
  • Köhler K. A. K., Walter K., Lang K., Müller B., Hoffrogge R., Blank L. M. and Schmid A. (2012)
    Eliminating drawbacks of recombinant n-butanol production by Pseudomonas sp. VLB120: identification of alcohol and aldehyde dehydrogenases involved in butanol metabolization.
    3rd annual CLIB-graduate cluster retreat, 22. - 24. February 2012, Bergisch-Gladbach, Germany
  • Lange K., Julsing M. K., Bühler B. and Schmid A. (2012)
    Functional expression of the THCA synthase from Cannabis sativa in E. coli.
    CLIB Retreat, February 22-24, 2012, Bergisch Galdbach, Germany
  • Rosenthal K., Frick O. and Schmid A. (2012)
    Single cell analysis of industrial relevant microorganisms.
    3rd annual CLIB-graduate cluster retreat, Bergisch-Gladbach, Germany
  • Dusny C., Fritzsch F. S. O., Rosenthal K., Parolina G., Frick O. and Schmid A. (2012)
    Beyond the bulk: Analysis and cultivation of single yeast and bacteria in precisely controlled extracellular environments (Best poster award).
    2nd BioProScale Symposium, 14. - 16. March 2012, Berlin, Germany
2011
  • Volmer J., Schmid A. and Bühler B. (2011)
    Solvent tolerant phenotypes of Pseudomonas sp. strain VLB120 - a chance to improve redox biocatalysis with toxic reactants?
    2nd Annual CLIB-Graduate cluster retreat, 7. April 2011, Bonn, Germany
  • Rosenthal K., Fritzsch F. S. O., Dusny C., Frick O., Blank L. M. and Schmid A. (2011)
    Single Cell Analysis in Biotechnology A: An Overview: From defined Microenvironments towards Systems Biology.
    Bubble Tech to Bio App – LAB-ON-A-CHIP, 17. - 18. October 2011, Saarbruecken, Germany
  • Fritzsch F. S. O., Rosenthal K., Dusny C., Kampert A., Kortmann H., Frick O., Blank L. M. and Schmid A. (2011)
    Single Cell Analysis in Biotechnology B: The Envirostat 2.0 – A next generation microfluidic platform for single cell analysis in controlled microenvironments.
    Bubble Tech to Bio App – LAB-ON-A-CHIP, 17. - 18. October 2011, Saarbruecken, Germany
  • Dusny C., Fritzsch F. S. O., Rosenthal K., Parolina G., Oehling V., Frick O., Blank L. M. and Schmid A. (2011)
    Single Cell Analysis in Biotechnology C: Time-resolved quantitative physiology of trapped single yeast and bacteria in defined microenvironments.
    Bubble Tech to Bio App – LAB-ON-A-CHIP, 17. - 18. October 2011, Saarbruecken, Germany
  • Karande R., Bühler K. and Schmid A. (2011)
    Applications of segmented flow microreactors for biocatalysis.
    Biotrends, 8. - 9. December 2011, Dortmund, Germany
  • Ladkau N., Hermann I., Bühler B. and Schmid A. (2011)
    Enzyme catalyzed laurolactam synthesis in aqueous solution.
    BioTrends 2011, 8.-9. December 2011, Dortmund, Germany
  • Schrewe M., Ladkau N., Lange K., Czarnotta E, Julsing M. K., Bühler B. and Schmid A. (2011)
    Multi-step whole-cell biocatalysis for the specific functionalization of unactivated terminal C‑H bonds.
    BioTrends 2011, 8. – 9. December 2011, Dortmund, Germany
  • Falcioni F., Eiden F. and Schmid A. (2011)
    ChemBioTec: a successful platform for sustainable chemical and biotechnological processes.
    Italian Industrial Biocatalysis Workshop, 29. November 2011, Milan, Italy
  • Collins J., Brandenbusch C., Sadowski G., Schmid A. and Bühler B. (2011)
    Dynamic cell based emulsions in biphasic biocatalytic systems and strategies for their downstream processing.
    Biotrans 2011, 2. - 6. October 2011, Giandini Naxos, Sicily, Italy
  • Ladkau N., Hermann I., Bühler B. and Schmid A. (2011)
    Enzyme catalyzed laurolactam synthesis via intramolecular amide-bond formation in aqueous solution.
    Biotrans 2011, 2.-6. October 2011, Giardini Naxos, Sicily, Italy
  • Julsing M. K., Schrewe M., Cornelissen S., Schmid A. and Bühler B. (2011)
    Improved biotransformation rates for hydrophobic substrates using ths outer membrane protein AlkL in E. coli.
    Biotrans 2011, 2. - 6. October 2011, Giardini Naxos, Sicily, Italy
  • Falcioni F., Frick O., Blank L. M., Schmid A. and Bühler B. (2011)
    Relationship between cell physiology and biocatalytic activity in E. coli expressing proline-4-hydroxylase.
    Biotrans 2011, 2. - 6. October 2011, Giardini Naxos, Sicily, Italy
  • Schrewe M., Ladkau N., Lange K., Czarnotta E, Julsing M. K., Bühler B. and Schmid A. (2011)
    Whole-cell biocatalysis for the controlled terminal functionalization of sp3 hybridized C‑H bonds.
    Biotrans 2011, 2. - 6. October 2011, Giardini Naxos, Sicily, Italy
  • Dusny C., Fritzsch F. S. O., Kortmann H., Blank L. M. and Schmid A. (2011)
    Towards quantitative physiology with single yeast.
    bio.dortmund, 28. September 2011, Dortmund, Germany
  • Lange K., Cornelissen S., Julsing M. K., Bühler B. and Schmid A. (2011)
    Biocatalyst design for the synthesis of cannabinoids in a microbial host: metabolic engineering for the production of monoterpenoids.
    1st European Congress of Applied Biotechnology, September 25-29, 2011, Berlin, Germany
  • Collins J., Brandenbusch C., Sadowski G., Schmid A. and Bühler B. (2011)
    Dynamic cell based emulsions in biphasic biocatalytic systems and strategies for their downstream processing.
    1st European Congress of Applied Biotechnology, 25. - 29. September 2011, Berlin, Germany
  • Tomaszewski B., Lutz J., Bühler K. and Schmid A. (2011)
    From an enzyme to a production process - stepwise design of a microreactor system.
    Marie Curie Researchers Symposium, 25. - 27. September 2011, Warsaw, Poland
  • Hillen M, Frick O., Falcioni F., Schmid A. and Bühler B. (2011)
    Metabolic analysis and optimization of a recombinant Escherichia coli as a biocatalyst for the production of trans-4-hydroxy-L-proline from L-proline.
    2ND SUMMER SCHOOL Biotransformations, 22. - 25. August 2011, Bad Herrenalb, Germany
  • Fritzsch F. S. O., Dusny C., Kortmann H., Blank L. M. and Schmid A. (2011)
    Single cell analysis.
    Nano! Nutzen und Visionen einer neuen Technology, DASA, 15. July 2011, Dortmund, Germany
  • Tomaszewski B., Lutz J., Bühler K. and Schmid A. (2011)
    Stabilization of biocatalysts for application in segmented flow microcapillary reactors.
    Bioverfahrenstechnik an Grenzflächen , 30. May - 1. June 2011, Potsdam, Germany
  • Bühler K., Halan B. and Schmid A. (2011)
    Biofilm catalysis: Impact of styrene on Pseudomonas sp. strain VLB120 biofilms.
    Bioverfahrenstechnik an Grenzflächen, 30. May - 1. June 2011, Potsdam, Germany
  • Lang K., Bühler K. and Schmid A. (2011)
    Development of an isobutanol producing biofilm catalyst.
    DECHEMA: Bioverfahrenstechnik an Grenzflächen, 30. May 2011, Potsdam, Germany
  • Lang K., Bühler K. and Schmid A. (2011)
    Development of an isobutanol producing biofilm catalyst.
    2nd Annual CLIB-graduate cluster retreat, 7. April 2011, Bonn, Germany
  • Köhler K. A. K., Malekina T., Blank L. M. and Schmid A. (2011)
    Optimization of biobutanol production: metabolic engineering and solvent tolerance.
    2nd Annual CLIB-graduate cluster retreat, 7. April 2011, Bonn, Germany
  • Lange K., Cornelissen S., Julsing M. K., Bühler B. and Schmid A. (2011)
    Production of cannabinoids in a microbial host: synthesis of THCA in E. coli.
    CLIB Retreat, April 7, 2011, Bonn, Germany
  • Lang K., Bühler B. and Schmid A. (2011)
    Development of an isobutanol producing biofilm catalyst.
    2nd CLIB international conference, 5. April 2011, Düsseldorf, Germany
  • Köhler K. A. K., Malekina T., Blank L. M. and Schmid A. (2011)
    Optimization of biobutanol production: Metabolic engineering and solvent tolerance.
    2nd CLIB international conference, 5. April 2011, Düsseldorf, Germany
  • Volmer J., Schmid A. and Bühler B. (2011)
    Solvent tolerant phenotypes of Pseudomonas sp. strain VLB120 - a chance to improve redox biocatalysis with toxic reactants?
    CLIB Conference, 5. - 6. April 2011, Düsseldorf, Germany
  • Fu J., Falcioni F., Bühler B., Bühler K. and Schmid A. (2011)
    Biochemical characterization of P4Hs: Towards hydroxyproline production by recombinant E. coli.
    DECHEMA Summerschool , September 2011, Bad Herrenalb, Germany
  • Volmer J., Neumann C., Schmid A. and Bühler B. (2011)
    Towards a stable solvent tolerant phenotype for redox biocatalysis with Pseudomonas sp. strain VLB120.
    1st European Congress of Applied Biotechnology, 25. – 29. September 2011, Berlin, Germany
  • Dusny C., Fritzsch F. S. O., Blank L. M. and Schmid A. (2011)
    Towards quantitative physiology with single yeast (Best poster award).
    Leibniz-Institute for Analytical Sciences – ISAS - e. V. Summer School 2011, 07. July 2011, Dortmund, Germany
2010
  • Volmer J., Bühler B. and Schmid A. (2010)
    Pseudomonas strains - a platform for redox biocatalysis.
    1st Annual CLIB-Graduate cluster retreat, 8. March 2010, Wuppertal, Germany
  • Ütkür F.Ö., Tran T.-T., Schmid A. and Bühler B. (2010)
    Development of a two-liquid phase process for oxyfunctionalizations catalyzed by dehyrogenase-containing microbial cells.
    ESBES (European Symposium on Biochemical Engineering Science), 5. - 8. September 2010, Bologna, Italy
  • Kuhn D., Zhang X., Fritzsch F. S. O., Blank L. M., Schmid A. and Bühler B. (2010)
    Systems biotechnological approach for intensification of a biocatalytic oxyfunctionalization process.
    ESBES (European Symposium on Biochemical Engineering Science), 5. - 8. September 2010, Bologna, Italy
  • Volmer J., Schmid A. and Bühler B. (2010)
    Solvent tolerant Pseudomonas strains - a platform for Redox Biocatalysis with Toxic Reactants.
    ESF-Bielefeld-CeBiTec Conference; Microbes and Industrial Biotechnology, 21.-24. November 2010, Bielefeld, Germany
  • Rühl J., Blank L. M. and Schmid A. (2010)
    Pseudomonas putida as host for biobutanol production.
    BioTrends 2010, 1. - 2. December 2010, Dortmund, Germany
  • Halan B., Letzel T., Bufe R., Bühler K. and Schmid A. (2010)
    Catalytic Biofilms: Real time solvent tolerance analysis and new frontiers in reactor design.
    BioTrends 2010, 1. - 2. December 2010, Dortmund, Germany
  • Ütkür F.Ö., Tran T.-T., Schmid A. and Bühler B. (2010)
    Development of a Two-Liquid Phase Process for Oxyfunctionalizations Catalyzed by Dehydrogenase-Containing Microbial Cells.
    BioTrends 2010, 1. - 2. December 2010, Dortmund, Germany
  • Falcioni F., Frick O., Blank L. M., Schmid A. and Bühler B. (2010)
    Microbial physiology determines the catalytic efficiency of proline hydroxylation by proline-4-hydroxylase.
    BioTrends 2010, 1. - 2. December 2010, Dortmund, Germany
  • Julsing M. K., Kuhn D., Schmid A. and Bühler B. (2010)
    Oxygenase catalyzed styrene epoxidation using non-growing E.coli cells in a two-liquid phase system.
    BioTrends 2010, 1. - 2. December 2010, Dortmund, Germany
  • Volmer J., Schmid A. and Bühler B. (2010)
    Solvent tolerant Pseudomonas strains - a platform for Redox Biocatalysis with Toxic Reactants.
    BioTrends, 1. - 2. December 2010, Dortmund, Germany
  • Fritzsch F. S. O., Dusny C., Kortmann H., Blank L. M. and Schmid A. (2010)
    Single Cell Analysis.
    ISAS - Evaluation, 30. September 2010, Dortmund, Germany
  • Ladkau N., Schrewe M., Bühler B. and Schmid A. (2010)
    Multistep-Biocatalysis for the production of 12-aminolauric acid methyl ester from lauric acid methyl ester with recombinant E. coli.
    EFB Bioprocess Engineering Course, 19. - 26. September 2010, Supetar, Croatia
  • Lang K., Bühler K. and Schmid A. (2010)
    Utilization of biofilms as biocatalysts for chemical synthesis.
    28. DECHEMA Jahrestagung der Biotechnologen und ProcessNet, 23. September 2010, Düsseldorf, germany
  • Blank L. M., Ebert B. E. and Schmid A. (2010)
    Analysis, design and optimization of bacterial networks for redox biocatalysis.
    Metabolic Engineering conference, 13. - 18. June 2010, Jeju, Korea
  • Karande R., Bühler K. and Schmid A. (2010)
    Asymmetric enzymatic hydrogenation in an aqueous/organic flow capillary microreaktor.
    Bioprozessorientiertes Anlagendesign, 10. - 12. Mai 2010, Nürnberg, Germany
  • Blank L. M., Heyland J., Fu J. and Schmid A. (2010)
    Protein production with Pichia pastoris: Is metabolism limiting?
    VAAM, 28. - 31. March 2010, Convention Center Hannover, Germany
  • Köhler K. A. K., Blank L. M. and Schmid A. (2010)
    Optimization of biobutanol production: Metabolic engineering and solvent tolerance.
    1st Annual CLIB-graduate cluster retreat, 8. March 2010, Wuppertal, Germany
  • Lang K., Bühler K. and Schmid A. (2010)
    Utilization of biofilms as biocatalysts for chemical synthesis.
    1st CLIB international conference: Value generating transformation of renewable carbon sources, 3. March 2010, Düsseldorf, Germany
  • Schmid A., Halan B. and Bühler K. (2010)
    Maximising the productivity of catalytic biofilms on solid supports in membrane bioreactors.
    DECHEMA Bioprozessorientiertes Anlagendesign, 10. - 12. May 2010, Nürnberg, Germany
  • Bühler B., Cornelissen S. and Schmid A. (2010)
    Cell physiology determines the efficiency of cytochrome P450-catalyzed C-H-oxyfunctionalization.
    Gordon Research Conference on Biocatalysis, 11. - 16. July 2010, Smithfield, RI, USA
  • Falcioni F., Frick O., Blank L. M., Schmid A. and Bühler B. (2010)
    Interrelation between α-ketoglutarate dependent proline hydroxylation and metabolic network operation in recombinant E. coli.
    Gordon Research Conference on Biocatalysis, 11. - 16. July 2010, Smithfield, RI, USA
  • Halan B., Letzel T., Bufe R., Bühler K. and Schmid A. (2010)
    Catalytic biofilms: Real time solvent tolerance analysis and new frontiers in reactor design.
    Gordon Research Conference on Biocatalysis, 11. - 16. July 2010, Smithfield, Rhode Island, USA
2009
  • Heyland J., Blank L. M. and Schmid A. (2009)
    Production of L-carnosine using recombinant whole cell biocatalysts.
    DECHEMA Jahrestagung der Biotechnologen, 8. - 10. September 2009, Mannheim, Germany
  • Rühl J., Blank L. M. and Schmid A. (2009)
    Selected P. putida strains can grow in the presence of high butanol concentrations.
    DECHEMA Jahrestagung der Biotechnologen, 8. - 10. September 2009, Mannheim, Germany
  • Schrewe M., Schmid A. and Bühler B. (2009)
    Application of a whole-cell biocatalyst for the omega-oxyfunctionalizationof fatty acid methyl ester.
    Biotrans 2009, 5th – 9th July 2009, Bern, Switzerland
  • Falcioni F., Kleinsteuber P., Bühler B. and Schmid A. (2009)
    How to improve proline hydroxylation in a whole-cell biocatalyst.
    Biotrans 2009, 5th – 9th July 2009, Bern, Switzerland
  • Julsing M. K., Kuhn D., Schmid A. and Bühler B. (2009)
    The potential of resting E. coli cells for oxygenase catalysis.
    Biotrans 2009, 5th – 9th July 2009, Bern, Switzerland
  • Bühler B., Cornelissen S., Liu S and Schmid A. (2009)
    Whole-cell biocatalysis: An efficient strategy for specific C-H oxyfunctionalizations - P450 catalysis.
    Biotrans 2009, 5th - 9th of July 2009, Bern, Switzerland
  • Julsing M. K., Kuhn D., Schmid A. and Bühler B. (2009)
    A comparison of resting and growing E. coli for oxygenase catalysis.
    DECHEMA Jahrestagung der Biotechnologen, 8. - 10. September 2009, Mannheim, Germany
  • Ütkür F.Ö., Sulu D. K., Schmid A. and Bühler B. (2009)
    Quinoline 2-oxidoreductase (Qor): A promising candidate for carbon oxyfunctionalizations.
    Biotrans 2009, 5. - 9. July 2009, Bern, Switzerland
  • Lutz J., Lang K., Heck T., Geueke B., Kohler H.-P. E., Blank L. M. and Schmid A. (2009)
    Towards enzymatic production of carnosine.
    Biotrans 2009, 5. - 9. July 2009, Bern, Switzerland
  • Cornelissen S., Liu S, Bühler B. and Schmid A. (2009)
    Substrate availability limits CYP153A6-catalyzed (S)-perillyl alcohol production in two-liquid phase biotransformations.
    16th International Conference on Cytochrome P450, Biochemistry, Biophysics, Biotechnology, 21. - 25. June 2009, Nago (Okinawa), Japan
  • Lutz J., Lang K., Lange K., Blank L. M. and Schmid A. (2009)
    Synthesis of carnosine using β-peptidases.
    ProStab2009 - 8th International Conference on Protein Stabilisation, 14. - 17. April 2009, Graz, Austria
  • Halan B., Bühler K. and Schmid A. (2009)
    Catalytic biofilms: novel concept for fine chemical synthesis.
    VAAM, 8. - 11. March 2009, Bochum, Germany
  • Gross R., Lang K., Hermes S., Bühler K. and Schmid A. (2009)
    Characterization and optimization of a novel biofilm reactor for fine chemical synthesis.
    VAAM, 8. - 11. March 2009, Bochum, Germany
  • Fritzsch F. S. O., Kortmann H., Blank L. M. and Schmid A. (2009)
    A reliable, rapid and easy-to-use world-to-chip interface.
    11th Status Seminar Chip Technologies, DECHEMA, 5.-6. March, Frankfurt, Germany
  • Karande R., Bühler K. and Schmid A. (2009)
    Multiphase slug flow microreactor for enzyme based redox biocatalysis.
    Dechema, Jahrestagung der Biotechnologen, 8. - 10. September 2009, Mannheim, Germany
  • Gross R., Bühler K. and Schmid A. (2009)
    Selective hydroxylation of alkanes with a membrane biofilm reactor.
    Biotrans, 2009, Bern, Switzerland
  • Fritzsch F. S. O., Kortmann H., Blank L. M. and Schmid A. (2009)
    The single cell ENVIROSTAT.
    ISAS - Scientific Consultant Meeting, 06. July 2009, Dortmund, Germany
  • Schmid A., Fritzsch F. S. O., Kortmann H. and Blank L. M. (2009)
    The single cell Envirostat.
    Gordon Research Conference on Applied & Environmental Microbiology, 12. - 17. July, South Hadley, MA, USA
2008
  • Brandenbusch C., Bühler B., Schmid A. and Sadowski G. (2008)
    Innovative down-stream processing in whole-cell biocatalysis using supercritical carbon dioxide.
    2. International Symposium on Biothermodynamics, Dechema, 21st-22nd of February 2008, Frankfurt, Germany
  • Rühl J., Blank L. M. and Schmid A. (2008)
    Solvent tolerant Pseudomonas: towards engineering of an improved biocatalyst for biobutanol production.
    Metabolic Engineering VII, 14.-19. September, Puerto Vallarta, Mexico
  • Kortmann H., Blank L. M. and Schmid A. (2008)
    The ENVIROSTAT - a new bioreactor concept for studying single cell physiology.
    Metabolic Engineering VII, 14.-19. September, Puerto Vallarta, Mexico
  • Bayraktar F. Ö., Gaykawad S., Schmid A. and Bühler B. (2008)
    Application of quinaldine 4-oxidase-containing recombinant P. putida as a biocatalyst in hydroxylation reactions.
    ESBES 2008, 7th - 10th of September, Faro, Portugal
  • Schrewe M., Bühler B. and Schmid A. (2008)
    Development of a productive whole-cell biocatalyst for ω-hydroxylation of fatty acid methyl esters.
    Biocat 2008, 31st of August - 4th of September 2008, Hamburg, Germany
  • Falcioni F., Kleinsteuber P., Bühler B. and Schmid A. (2008)
    Microbial proline-hydroxylase: a model for α-ketoglutarate dependent oxygenases.
    Biocat 2008, 31st of August - 4th of September, Hamburg, Germany
  • Bühler B., Bayraktar F. Ö., Gaykawad S. and Schmid A. (2008)
    Application of molybdenum-containing dehydrogenases for carbon oxyfunctionalization.
    Gordon Conference on Biocatalysis 2008, 6th - 11th of July 2008, Smithfield, RI, USA
  • Bühler K., Gross R., Halan B., Hermes S. and Schmid A. (2008)
    Biofilms: Versatile Biocatalysts for Redox-Catalysis?
    Gordon Research Conference on Biocatalysis, 6. - 11. July 2008, Bryant University, Smithfield, RI, USA
  • Kortmann H., Blank L. M. and Schmid A. (2008)
    The ENVIROSTAT - a new reactor concept for single cell physiology.
    4th Int. Conference on Analysis of Microbial Cells at the Single Cell Level, 22.-24. May 2008, Bad Schandau, Germany
  • Kurth F., Schumann C. A., Kortmann H., Blank L. M., Schmid A., Manz A. and Dittrich P. (2008)
    A bilayer microfluidic chip for diffusion-controlled activation of yeast species.
    Methods for Systems Biology MSB08, 9. - 13. March 2008, Berlin, Germany
  • Karande R., Bühler K. and Schmid A. (2008)
    Asymmetric Enzymatic Hydrogenation in Capillary Microreactors.
    MSB, 9. - 13. March 2008, Berlin, Germany
  • Ebert B. E., Blank L. M. and Schmid A. (2008)
    Genome-scale metabolic model of Pseudomonas putida KT2440.
    VAAM, 9. - 11. March 2008, Frankfurt/Main, Germany
  • Geltenpoth H., Hein E. M., Blank L. M., Schmid A. and Hayen H. (2008)
    In-depth analysis of baker's yeast metabolism: central carbon metabolism.
    Methods for Systems Biology MSB08, 9. - 13. March 2008, Berlin, Germany
  • Hein E. M., Blank L. M., Schmid A. and Hayen H. (2008)
    In-depth analysis of baker's yeast metabolism: glycerophospholipids.
    Methods for Systems Biology MSB08, 9. - 13. March 2008, Berlin, Germany
  • Blank L. M., Hein E. M., Schmid A. and Hayen H. (2008)
    In-depth analysis of baker's yeast metabolism: metabolic fluxes.
    Methods for Systems Biology MSB08, 9. - 13. March 2008, Berlin, Germany
  • Rühl J., Blank L. M. and Schmid A. (2008)
    Quantitative analysis of glucose utilization by Pseudomonas putida KT2440.
    VAAM, 9. - 11. March 2008, Frankfurt, Germany
  • Kortmann H., Blank L. M. and Schmid A. (2008)
    The Envirostat - precise environmental controlled cultivation on μscale.
    Methods for Systems Biology MSB08, 9. - 13. March 2008, Berlin, Germany
  • Hein E. M., Blank L. M., Schmid A. and Hayen H. (2008)
    Phospholipid profiling of yeast.
    PittCon 2008, 2. - 7. March 2008, New Orleans, USA
  • Ebert B. E., Blank L. M. and Schmid A. (2008)
    Genome-scale metabolic model of Pseudomonas putida KT2440.
    2nd International Symposium on Biothermodynamics, 21. - 22. February 2008, Frankfurt/Main, Germany
  • Brandenbusch C., Bühler B., Schmid A. and Sadowski G. (2008)
    Innovative down-stream processing in whole-cell biocatalysis using supercritical carbon dioxide.
    2nd International Symposium on Biothermodynamics, 21. - 22. February 2008, Frankfurt/Main, Germany
  • Wierckx N. J. P., Blank L. M., de Winde H., Schmid A. and Ruijssenaars H. J. (2008)
    Metabolic flux analysis of a phenol producing mutant of Pseudomonas putida S12.
    Kluyver Center, 29. - 30. January 2008, Delft, The Netherlands
2007
  • Kortmann H., Blank L. M. and Schmid A. (2007)
    Cultivation of dielectrophoretically trapped single cells under optimal environmental conditions.
    11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 7. - 11. October 2007, Paris, France
  • Cornelissen S., Julsing M. K., Bühler B. and Schmid A. (2007)
    Evaluation of different recombinant microorganisms expressing mammalian CYP1A1 for productive whole-cell biocatalysis.
    15th International Conference on Cytochromes P450, Biophysics and Functional Genomics, 17. - 21. July 2007, Bled, Slovenia
  • Bayraktar F. Ö., Bühler B. and Schmid A. (2007)
    Application of molybdenum-containing hydroxylases in hydroxylation reactions.
    Biotrans 2007 - 8th International Symposium on Biocatalysis and Biotransformations, 8. - 13. July 2007, Ovideo, Spain
  • Bühler B., Kuhn D., Park J. B., Blank L. M. and Schmid A. (2007)
    Evaluation of the efficiency of recombinant Escherichia coli as an epoxidation catalysts by a systems biotechnology approach.
    Biotrans 2007 - 8th International Symposium on Biocatalysis and Biotransformations, 8. - 13. July 2007, Ovideo, Spain
  • Ruinatscha R., Otto K. and Schmid A. (2007)
    Integrated concepts for efficient coupling of styrene monooxygenase (StyA) with electrochemical cofactor regeneration.
    Biotrans 2007 - 8th International Symposium on Biocatalysis and Biotransformations, 8. - 13. July 2007, Ovideo, Spain
  • Höllrigl V., Otto K. and Schmid A. (2007)
    Production and characterization of the thermophilic alcohol dehydrogenase from Thermus sp. for biotechnological applications.
    Biotrans 2007 - 8th International Symposium on Biocatalysis and Biotransformations, 8. - 13. July 2007, Ovideo, Spain
  • Kortmann H., Blank L. M. and Schmid A. (2007)
    A single cell analysis platform for Saccharomyces cerevisiae.
    European BioPerspectives, 30. May - 1. June 2007, Cologne, Germany
  • Höllrigl V., Otto K. and Schmid A. (2007)
    Application of electroenzymatic reductions to organic synthesis.
    European BioPerspectives, 30. May - 1. June 2007, Cologne, Germany
  • Blank L. M., Ionidis G., Bühler B. and Schmid A. (2007)
    Estimation of the microbial redox cofactor regeneration rate.
    European BioPerspectives, 30. May - 1. June 2007, Cologne, Germany
  • Ebert B. E., Blank L. M., Bühler B. and Schmid A. (2007)
    Metabolic capacity estimation of Escherichia coli as platform for redox biocatalysis.
    European BioPerspectives, 30. May - 1. June 2007, Cologne, Germany
  • Heyland J., Blank L. M. and Schmid A. (2007)
    Metabolic flux analysis in Saccaromyces cerevisiae based on 13C labeled proteinogenic amino acids of the secretome.
    European BioPerspectives, 30. May - 1. June 2007, Cologne, Germany
  • Otto K., Gross R., Hauer B. and Schmid A. (2007)
    The potential of biofilms for redox biocatalysis.
    4th ASM Conference on Biofilms, 25. - 29. March 2007, Québec, Canada
  • Ebert B. E., Blank L. M., Bühler B. and Schmid A. (2007)
    Using constraint-based modeling to estimate Escherichia colis capacity for redox biocatalysis.
    2nd FEBS Advanced Lecture Course on Systems Biology, 11. - 16. March 2007, Gosau, Austria
  • Kortmann H., Blank L. M. and Schmid A. (2007)
    Establishing a single cell bioreactor for Saccaromyces cerevisiae.
    Statusseminar Chiptechnologien, 1. - 2. February 2007, Frankfurt, Germany
  • Kuhn D., Kholiq A., Heinzle E., Bühler B. and Schmid A. (2007)
    Sustainability evaluation and optimization of a biocatalytic two-liquid phase epoxidation process.
    Biotrans 2007 - 8th International Symposium on Biocatalysis and Biotransformations, 8. - 13. July 2007, Oviedo, Spain
2006
  • Kortmann H., Blank L. M. and Schmid A. (2006)
    Single cell analysis.
    Bioband, 16. October 2006, Dortmund, Germany
  • Blank L. M., Ebert B. E., Bühler B. and Schmid A. (2006)
    Metabolic capacitiy of biocatalytic active microbes.
    6th Metabolic Engineering Conference, 1. - 5. October 2006, Nordwijkerhout, Netherlands
  • Blank L. M., Ebert B. E., Bühler B. and Schmid A. (2006)
    Constrained based modelling for metabolic capacity estimation of Escherichia coli as platform for redox biocatalysis.
    From µl to m3 - Strategies in bioprocess development, 28. - 29. March 2006, Hamburg, Germany
  • Bühler B., Park J. B. and Schmid A. (2006)
    Recombinant whole-cell biocatalysis for highly selective epoxidation - a comparison of resting and growing cells.
    From µl to m3 - Strategies in bioprocess development, 28. - 29. March 2006, Hamburg, Germany
  • Blank L. M., Ionidis G., Bühler B. and Schmid A. (2006)
    Quantitative physiology of microbes; metabolic capacitiy of Pseudomonas putida for biocatalysis.
    20th International Symposium on Micro-Scale Bioseparations, 21. - 25. January 2006, Amsterdam, Netherlands
2005
  • Höllrigl V., Hollmann F., Kleeb A., Otto K. and Schmid A. (2005)
    Enantioselective cell-free bioreductions coupled ton non-enzymatic cofactor regeneration.
    Biotrans 2005 - 7th International Symposium on Biocatalysis and Biotransformations, 3. - 8. July 2005, Delft, Netherlands
  • Meyer D., Kehl P., Witholt B. and Schmid A. (2005)
    The role of host-intrinsic enzyme activities of recombinant bacteria in biocatalytic applications.
    Biotrans 2005 - 7th International Symposium on Biocatalysis and Biotransformations, 3. - 8. July 2005, Delft, Netherlands
  • Blank L. M., Ionidis G. and Schmid A. (2005)
    Metabolic capacity of Pseudomonas putida as biocatalyst inferred from 13C tracer experiments.
    3rd International Conference on Analysis of Microbial Cells at Single Cell Level, 26. - 28. May 2005, Semmering, Austria
2004
  • Bühler B., Straathof A. J. J., Witholt B. and Schmid A. (2004)
    Modeling and simulation of a whole-cell multistep biooxidation process in a two liquid phase system.
    5th D-BIOL Symposium, 19. - 21. May 2004, Davos, Switzerland
2003
  • Yildrim S., Ruinatscha R., Wohlgemuth R., Kohler H.-P. E., Witholt B. and Schmid A. (2003)
    Biotransformation of aromatic nitriles to cis-dihydrodiols using chlorobenzene dioxygenases in Escherichia coli as biocatalyst.
    11th European Congress on Biotechnology, 24. - 29. August 2003, Basel, Switzerland
  • Bühler B., Straathof A. J. J., Witholt B. and Schmid A. (2003)
    Modeling and simulation of a whole-cell multistep biooxidation process in a two liquid phase system.
    11th European Congress on Biotechnology, 24. - 29. August 2003, Basel, Switzerland
2002
  • Bühler B., Bollhalder I., Feiten H.-J., Hauer B., Witholt B. and Schmid A. (2002)
    Pilot-scale production of 3,4-Dimethylbenzaldehyde from pseudocumene via multistep biocatalysis in a Xylene Monooxygenase based two-liquid phase process.
    4th D-BIOL Symposium, 8. - 10. May 2002, Davos, Switzerland

Varia

Organized Symposia

General

  • Schmid A. and Neubauer P. (2010)
    Analytical biotechnology: From single molecule and single cell analyses to population dynamics of metabolites and cells
    Current Opinion in Biotechnology, in press, DOI-Link
     
  • Schmid A., Bühler B., Bauer, B., Chmiel H., Hauer B., Habicher T., Krumbholz R. (2003)
    Prozessintegrierte rekombinante Biokatalyse für hochselektive Oxyfunktionalisierungen von Kohlenwasserstoffen.
    transkript, special issue 'Nachhaltige Biokatalyse':110-112

  • Schmid A. (2001)
    Interview: "Biokatalyse in unwirtlicher Umgebung" aus: "Bio" in der Chemie - die Zukunft hat begonnen.

    focus Prozess-BioTeCH
    , 1:(2-4), im Rahmen des Schwerpunktprogramms Biotechnologie des Schweizer Nationalfonds, http://www.bioweb.ch/, PDF-File 

  • Engesser K.-H., Schmid A. (1994)
    Einsatz von Gensonden zur Identifikation von Mikroorgansimen im belebten Schlamm.
    Siedlungswasserwirtschaftliches Kolloquium
    , 128:149-165


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