People

Dr. Oliver Frick

Dr. Oliver Frick
Dr. Oliver Frick
Umweltforschungszentrum Leipzig
Department Solar Materials
Gebäude 9.2 Kubus Raum 411
04318 Leipzig
Germany

Tel.: +49-341-235 4688
Fax.: +49-341-235-45 1286

E-Mail:



Resume

Oliver Frick dedicates his main research interests to microbial physiology and metabolism with a major focus on the physiology of photosynthetically active bacteria and microbial consortia. Of particular interest is the response of metabolic networks to introduced genetic and environmental perturbations. This contributes to a better understanding of interrelations between different cellular processes and is a prerequisite for rational cell engineering approaches for the generation of valuable chemical compounds.
Publications
Peer Reviewed Articles
2016
  • Oehling V., Klaassen P., Schmid A. and Frick O. (2016)
    Arabinose triggers its own uptake via induction of the arabinose specific Gal2p transporter in an arabinose fermenting Saccharomyces cerevisiae strain.
    Submitted
2015
  • Rosenthal K., Falke F., Frick O., Dusny C. and Schmid A. (2015)
    An inert continuous microreactor for the isolation and analysis of a single microbial cell.
    Micromachines, 6(12):1836-1855, DOI-Link
  • Köhler K. A. K., Blank L. M., Frick O. and Schmid A. (2015)
    D-Xylose assimilation via the Weimberg pathway by solvent tolerant Pseudomonas taiwanensis VLB120.
    Environmental Microbiology, 17(1):156-170, DOI-Link
  • Theodosiou E., Frick O., Bühler B. and Schmid A. (2015)
    Metabolic network capacity of Escherichia coli for Krebs cycle-dependent proline hydroxylation.
    Microbial Cell Factories, 14:108, DOI-Link
2013
  • Falcioni F., Blank L. M., Frick O., Karau A., Bühler B. and Schmid A. (2013)
    Proline availability regulates proline-4-hydroxylase synthesis and substrate uptake in proline-hydroxylating recombinant Escherichia coli.
    Applied and Environmental Microbiology, 79(9):3091-3100, DOI-Link
2012
  • Dusny C., Fritzsch F. S. O., Frick O. and Schmid A. (2012)
    Isolated Microbial Single Cells and Resulting Micropopulations Grow Faster in Controlled Environments.
    Applied and Environmental Microbiology, 78(19):7132-7136, DOI-Link
  • Fritzsch F. S. O.*, Dusny C.*, Frick O. and Schmid A. (2012)
    Single Cell Analysis in Biotechnology, Systems Biology, and Biocatalysis.
    Annual Review of Chemical and Biomolecular Engineering, 3:129-155, DOI-Link
    * These authors contributed equally to this work.
Oral Presentations
2011
  • Frick O. (2011)
    Towards single cell systems biotechnology - cultivation and analytics.
    Trends in Metabolomics - Analytics and Applications, 19. May 2011, Frankfurt am Main, Germany
Posters
2015
  • Grund M., Frick O., Bühler B. and Schmid A. (2015)
    Towards quantitative physiology in cyanobacteria by isotopically instationary 13C-metabolic flux analysis .
    DECHEMA Summer School Quantitative Biology 2015, 20. - 24. July 2015, Berlin, Germany
  • Oehling V., Frick O., Klaassen P. and Schmid A. (2015)
    L-arabinose utilization by industrially relevant Saccharomyces cerevisiae.
    5th BE-Basic Symposium, 31. March. - 1. April 2015, Noordwijk, the Netherlands
2014
  • Grund M., Frick O., Bühler B. and Schmid A. (2014)
    Metabolic Engineering of Cyanobacteria as Efficient Industrial Biocatalysts.
    DECHEMA Summer School Biotransformations 2014, 24. - 27. August 2014, Bad Herrenalb, Germany
  • Rosenthal K., Dusny C., Oehling V., Frick O. and Schmid A. (2014)
    Analysis of a single-cell: Imprisoned, but feeling well.
    5th annual CLIB-graduate cluster retreat, 12. – 14. February 2014, Lünen, Germany
  • Rosenthal K., Dusny C., Oehling V., Frick O. and Schmid A. (2014)
    The Envirostat 3.0: Microfluidic chip development for sampling of metabolites secreted by a single cell.
    3rd BioProScale Symposium, 02. - 04. March 2014, Berlin, Germany
2013
  • Falcioni F., Theodosiou E., Frick O., Schmid A. and Bühler B. (2013)
    Whole-cell biocatalysis for the conversion of L-proline to trans-4-hydroxy-L-proline with high specificity, yield, and productivity.
    Biotrans 2013, 21. - 25. July 2013, Manchester, UK
  • Rosenthal K., Fritzsch F. S. O., Dusny C., Oehling V., Frick O. and Schmid A. (2013)
    The Way for Single Cell Analysis: Pick the right, hold it tight, - then do a sight, if it’s bright.
    4th annual CLIB-graduate cluster retreat, 13. – 15. February 2013, Lünen, Germany
  • Oehling V., Fritzsch F. S. O., Dusny C., Rosenthal K., Kortmann H., Frick O. and Schmid A. (2013)
    Single cell analysis of ethanol producing Saccharomyces cerevisiae.
    3rd BE-Basic Symposium, 5. - 7. February 2013, Noordwijkerhout, The Netherlands
2012
  • Theodosiou E., Frick O., Bühler B. and Schmid A. (2012)
    Metabolic engineering of E.coli for the production of trans-4-hydroxy-L-proline.
    Metabolic Engineering IX, 3. - 7. June 2012, Biarritz, France
  • Dusny C., Fritzsch F. S. O., Rosenthal K., Frick O. and Schmid A. (2012)
    Quantitative physiology with isolated single cells and micropopulations in controlled microenvironments employing a picoliter bioreactor.
    The 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS), 28. October – 1. November 2012, Okinawa, Japan
  • Rosenthal K., Fritzsch F. S. O., Dusny C., Oehling V., Frick O. and Schmid A. (2012)
    Fluoreszenz gestützte Analytik von Mikroorganismen im mikrofluidischen Einzelzellreaktor.
    ProcessNet-Jahrestagung, 10. - 13. September 2012, Karlsruhe, Germany
  • Rosenthal K., Fritzsch F. S. O., Dusny C., Frick O., Blank L. M. and Schmid A. (2012)
    An Overview: Microbioreactors and Analytics for Systems biology on Single Cell Level.
    2nd BioProScale Symposium, 14. - 16. March 2012, Berlin, Germany
  • Fritzsch F. S. O., Oehling V., Rosenthal K., Dusny C., Kampert A., Kortmann H., Frick O., Blank L. M. and Schmid A. (2012)
    Contactless single cell analysis of industrial relevant bacteria in controlled microenvironments.
    2nd BioProScale Symposium, 14. - 16. March 2012, Berlin, Germany
  • Rosenthal K., Frick O. and Schmid A. (2012)
    Single cell analysis of industrial relevant microorganisms.
    3rd annual CLIB-graduate cluster retreat, Bergisch-Gladbach, Germany
  • Dusny C., Fritzsch F. S. O., Rosenthal K., Parolina G., Frick O. and Schmid A. (2012)
    Beyond the bulk: Analysis and cultivation of single yeast and bacteria in precisely controlled extracellular environments (Best poster award).
    2nd BioProScale Symposium, 14. - 16. March 2012, Berlin, Germany
2011
  • Rosenthal K., Fritzsch F. S. O., Dusny C., Frick O., Blank L. M. and Schmid A. (2011)
    Single Cell Analysis in Biotechnology A: An Overview: From defined Microenvironments towards Systems Biology.
    Bubble Tech to Bio App – LAB-ON-A-CHIP, 17. - 18. October 2011, Saarbruecken, Germany
  • Fritzsch F. S. O., Rosenthal K., Dusny C., Kampert A., Kortmann H., Frick O., Blank L. M. and Schmid A. (2011)
    Single Cell Analysis in Biotechnology B: The Envirostat 2.0 – A next generation microfluidic platform for single cell analysis in controlled microenvironments.
    Bubble Tech to Bio App – LAB-ON-A-CHIP, 17. - 18. October 2011, Saarbruecken, Germany
  • Dusny C., Fritzsch F. S. O., Rosenthal K., Parolina G., Oehling V., Frick O., Blank L. M. and Schmid A. (2011)
    Single Cell Analysis in Biotechnology C: Time-resolved quantitative physiology of trapped single yeast and bacteria in defined microenvironments.
    Bubble Tech to Bio App – LAB-ON-A-CHIP, 17. - 18. October 2011, Saarbruecken, Germany
  • Falcioni F., Frick O., Blank L. M., Schmid A. and Bühler B. (2011)
    Relationship between cell physiology and biocatalytic activity in E. coli expressing proline-4-hydroxylase.
    Biotrans 2011, 2. - 6. October 2011, Giardini Naxos, Sicily, Italy
  • Hillen M, Frick O., Falcioni F., Schmid A. and Bühler B. (2011)
    Metabolic analysis and optimization of a recombinant Escherichia coli as a biocatalyst for the production of trans-4-hydroxy-L-proline from L-proline.
    2ND SUMMER SCHOOL Biotransformations, 22. - 25. August 2011, Bad Herrenalb, Germany
2010
  • Falcioni F., Frick O., Blank L. M., Schmid A. and Bühler B. (2010)
    Microbial physiology determines the catalytic efficiency of proline hydroxylation by proline-4-hydroxylase.
    BioTrends 2010, 1. - 2. December 2010, Dortmund, Germany
  • Falcioni F., Frick O., Blank L. M., Schmid A. and Bühler B. (2010)
    Interrelation between α-ketoglutarate dependent proline hydroxylation and metabolic network operation in recombinant E. coli.
    Gordon Research Conference on Biocatalysis, 11. - 16. July 2010, Smithfield, RI, USA


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