People

Dipl.-Ing. Nadine Ladkau

Dipl.-Ing. Nadine Ladkau
Dipl.-Ing. Nadine Ladkau
Laboratory of Chemical Biotechnology
Technische Universität Dortmund
G1-4.21
44227 Dortmund
Germany

Tel.: +49-231-755 7381
Fax.: +49-231-755 7382

E-Mail:

Resume

Nadine Ladkau (*1984) studied Biochemical Engineering at the Faculty of Chemical and Biochemical Engineering at Technische Universität Dortmund (2003 - 2009). During an internship at Boehringer Ingelheim microParts, her work was focussed on the development of microfluidic products for clinical diagnostics. In her diploma thesis at the Laboratory of Chemical Biotechnology, she worked on the coupling of oxygenases and transaminases in vivo.

In February 2010 she started her PhD thesis in the Applied Biocatalysis group at the Laboratory of Chemical Biotechnology under supervision of Prof. Dr. Andreas Schmid and Dr. Bruno Bühler. Her research is focussed on sequential ω-oxy- and aminofunctionalization of hydrocarbons using whole-cell biocatalysts.

Publications
Peer Reviewed Articles
2016
  • Ladkau N., Aßmann M., Schrewe M., Julsing M. K., Schmid A. and Bühler B. (2016)
    Efficient production of the Nylon 12 monomer ω-aminododecanoic acid methyl ester from renewable dodecanoic acid methyl ester with engineered Escherichia coli.
    Metabolic Engineering, 36:1-9, DOI-Link
2014
  • Ladkau N., Schmid A. and Bühler B. (2014)
    The microbial cell - functional unit for energy-dependent multistep biocatalysis.
    Current Opinion in Biotechnology, 30:178-189, DOI-Link
2013
  • Schrewe M., Ladkau N., Bühler B. and Schmid A. (2013)
    Direct terminal alkylamino-functionalization via multistep biocatalysis in one recombinant whole-cell catalyst.
    Advanced Synthesis and Catalysis, 355(9):1693-1697, DOI-Link
2011
  • Ladkau N., Hermann I., Bühler B. and Schmid A. (2011)
    Enzyme catalyzed laurolactam synthesis via intramolecular amide bond formation in aqueous solution.
    Advanced Synthesis and Catalysis, 353(13):2501-2510, DOI-Link
Patent applications
2011
  • Schmid A., Bühler B., Ladkau N. and Hermann I. (2011)
    Method for omega-aminocarboxylic acid condensation.
    Europe, WO/2012/156151 / PCT/EP2012/056251 / priority: 11004029.2 16.05.2011 EP
Oral Presentations
2012
  • Ladkau N., Schrewe M., Julsing M. K., Bühler B. and Schmid A. (2012)
    Specific terminal oxy- and aminofunctionalization of dodecanoic acid methyl ester coupled in a single whole-cell catalyst.
    Gordon Research Seminar Biocatalysis, 7. - 8. July 2012, Smithfield, RI, USA
  • Ladkau N., Schrewe M., Julsing M. K., Schmid A. and Bühler B. (2012)
    Sequential ω-oxy- and aminofunctionalization of dodecanoic acid methyl ester.
    MECP12 (Multistep Enzyme-Catalyzed Processes), 10. - 13. April 2012, Graz, Austria
Posters
2014
  • Ladkau N., Schrewe M., Schmid A. and Bühler B. (2014)
    Three-step sequential whole-cell biocatalysis for the technical scale production of 12-aminododecanoic acid methyl ester from renewables.
    3rd Multistep Enzyme Catalyzed Processes Congress (MECP14), 7. - 10. April 2014, Madrid, Spain
2013
  • Schrewe M., Ladkau N., Lange K., Czarnotta E, Julsing M. K., Bühler B. and Schmid A. (2013)
    Reaction and catalyst engineering for whole-cell-based multistep ω-functionalization of renewables: Sustainable and efficient production of bifunctional building blocks for polymer syntheses.
    Biotrans 2013, 21. - 25. July 2013, Manchester, UK
  • Ladkau N., Schrewe M., Aßmann M., Klassen G., Bühler B. and Schmid A. (2013)
    Strain engineering for the omega-aminofunctionalization of dodecanoic acid methyl ester via multistep biocatalysis.
    Biotrans 2013, 21. - 25. July 2013, Manchester, UK
2012
  • Ladkau N., Schrewe M., Julsing M. K., Bühler B. and Schmid A. (2012)
    Specific terminal oxy- and aminofunctionalization of dodecanoic acid methyl ester coupled in a single whole-cell catalyst.
    Gordon Research Conference Biocatalysis, 8. - 13. July 2012, Smithfield, RI, USA
2011
  • Ladkau N., Hermann I., Bühler B. and Schmid A. (2011)
    Enzyme catalyzed laurolactam synthesis in aqueous solution.
    BioTrends 2011, 8.-9. December 2011, Dortmund, Germany
  • Schrewe M., Ladkau N., Lange K., Czarnotta E, Julsing M. K., Bühler B. and Schmid A. (2011)
    Multi-step whole-cell biocatalysis for the specific functionalization of unactivated terminal C‑H bonds.
    BioTrends 2011, 8. – 9. December 2011, Dortmund, Germany
  • Ladkau N., Hermann I., Bühler B. and Schmid A. (2011)
    Enzyme catalyzed laurolactam synthesis via intramolecular amide-bond formation in aqueous solution.
    Biotrans 2011, 2.-6. October 2011, Giardini Naxos, Sicily, Italy
  • Schrewe M., Ladkau N., Lange K., Czarnotta E, Julsing M. K., Bühler B. and Schmid A. (2011)
    Whole-cell biocatalysis for the controlled terminal functionalization of sp3 hybridized C‑H bonds.
    Biotrans 2011, 2. - 6. October 2011, Giardini Naxos, Sicily, Italy
2010
  • Ladkau N., Schrewe M., Bühler B. and Schmid A. (2010)
    Multistep-Biocatalysis for the production of 12-aminolauric acid methyl ester from lauric acid methyl ester with recombinant E. coli.
    EFB Bioprocess Engineering Course, 19. - 26. September 2010, Supetar, Croatia


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