Dr. Jan Heyland

Dr. Jan Heyland
Dr. Jan Heyland
Laborleiter Entwicklung
Nordmark Arzneitmittel GmbH & Co. KG
Pinauallee 4
25436 Uetersen

Tel.: +49-4122-712-907
Fax.: +49-4122-712-545



Jan Heyland was PhD student at the Laboratory of Chemical Biotechnology - Department of Biochemical and Chemical Engineering - at the Dortmund University of Technology (Dortmund, Germany). He studied Biotechnology in the Faculty of Life Sciences at the Hamburg University of Applied Sciences (Hamburg, Germany). For an external traineeship during his studies, he worked in the Department of Chemical Engineering at the University of Queensland (Brisbane, Australia) on hyaluronic acid production in bacteria. The work for his diploma degree (2004) in the field of S. cerevisiae physiology was performed at the Swiss Federal Institute of Technology Zürich in the Department of Biotechnology. Afterwards he worked as a project engineer in the Department of Process Engineering at the Nordmark GmbH & Co. KG (Uetersen, Germany). In 2006 he received his M.Sc. degree in Bioprocess Engineering at the Hamburg University of Applied Sciences. His master thesis was performed at the Hamburg University of Technology (Hamburg, Germany), where he worked on in vitro engineering of articular cartilage.

Research Area

Quantification of metabolic fluxes is an important analysis technique of metabolic engineering. Metabolic flux analysis provides insights into cellular physiology and thus, knowledge about the response of the intracellular carbon flux distribution in response to genetic modifications or environmental stress. Our focus is on the metabolic response of recombinant yeasts to foreign protein production in industrial relevant processes.

Funded by ChemBioTec (DBU)

Peer Reviewed Articles
  • Heyland J., Fu J., Blank L. M. and Schmid A. (2011)
    Carbon metabolism limits recombinant protein production in Pichia pastoris.
    Biotechnology and Bioengineering, 108(8):1942-1953, DOI-Link, PubMed
  • Heyland J., Blank L. M. and Schmid A. (2011)
    Quantification of metabolic limitations during recombinant protein production in Escherichia coli.
    Journal of Biotechnology, 155(2):178-184, DOI-Link, PubMed
  • Heyland J., Fu J., Blank L. M. and Schmid A. (2010)
    Quantitative physiology of Pichia pastoris during glucose-limited high cell-density fed-batch cultivation for recombinant protein production.
    Biotechnology and Bioengineering, 107(2):357-368, DOI-Link, PubMed
  • Heyland J., Antweiler N., Lutz J., Heck T., Geueke B., Kohler H.-P. E., Blank L. M. and Schmid A. (2010)
    Simple enzymatic procedure for carnosine synthesis: whole-cell biocatalysis and efficient biocatalyst recycling.
    Microbial Biotechnology, 3(1):74-83, DOI-Link, PubMed
  • Heyland J., Fu J. and Blank L. M. (2009)
    Correlation between TCA cycle flux and glucose uptake rate during respiro-fermentative growth of Saccharomyces cerevisiae.
    Microbiology, 155:3827-3837, DOI-Link, PubMed
  • Hein E. M., Blank L. M., Heyland J., Baumbach J. I., Schmid A. and Hayen H. (2009)
    Glycerophospholipid profiling by HPLC/MS using exact mass measurements and MSn fragmentation experiments in parallel.
    Rapid Communications in Mass Spectrometry, 23(11):1636-1646, DOI-Link, PubMed
  • Heyland J., Wiegandt K., Goepfert C., Nagel-Heyer S., Ilnich E., Schumacher U. and Pörtner R. (2006)
    Redifferentiation of chondrocytes and cartilage formation unter intermittent hydrostatic pressure.
    Biotechnology Letters, 28(20):1641-1648, DOI-Link, PubMed
  • Blank L. M., Heyland J., Fu J. and Schmid A. (2010)
    Protein production with Pichia pastoris: Is metabolism limiting?
    VAAM, 28. - 31. March 2010, Convention Center Hannover, Germany
  • Heyland J., Blank L. M. and Schmid A. (2009)
    Production of L-carnosine using recombinant whole cell biocatalysts.
    DECHEMA Jahrestagung der Biotechnologen, 8. - 10. September 2009, Mannheim, Germany
  • Heyland J., Blank L. M. and Schmid A. (2007)
    Metabolic flux analysis in Saccaromyces cerevisiae based on 13C labeled proteinogenic amino acids of the secretome.
    European BioPerspectives, 30. May - 1. June 2007, Cologne, Germany
  • Wiegandt K., Heyland J., Goepfert C., Nagel-Heyer S., Ilnich E., Schumacher U. and Pörtner R. (2006)
    Effect of intermittent loading redifferentiation of chondrocytes and cartilage formation.
    5th World Congress of Biomechanics, 29. July - 4. August 2006, Munich, Germany

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