People

Prof. Dr. Lars M. Blank

Prof. Dr. Lars M. Blank
Prof. Dr. Lars M. Blank
Institute of Applied Microbiology
RWTH Aachen
Worringer Weg 1
52074 Aachen
Germany

Tel.: +49-241-80 26600
Fax.: +49-241-80 22180

E-Mail:

Resume

Lars M. Blank studied Chemical Engineering from 1990 to 1997 at the University of Dortmund (Germany) and Biology from 1992 to 1997 at the Ruhr-University of Bochum (Germany). During his master theses he worked in the field of Metabolic Engineering in the group of Prof. E. T. Papoutsakis at Northwestern University, IL, USA and in yeast cell biology in the group of Prof. W.-H. Kunau at the Ruhr-University of Bochum. In his Ph.D. in the group of Prof. L. K. Nielsen at the University of Queensland, Australia (1998 to 2002), he developed a continuous process for hyaluronic acid production using lactic acid bacteria. During his Ph.D. he worked as a visiting scientist at the Technical University of Denmark (DtU), Lyngby, Denmark (Sept. - Dec. 1999), reprogramming Lactococcus lactis from a purely anaerobe to a partially respiratory organism. As a postdoctoral fellow of the Deutsche Akademie der Naturforscher Leopoldina (Halle, Germany) he established flux analysis as an additional tool for yeast Systems Biology in the group of Prof. U. Sauer at the ETH Zurich, Switzerland. From November 2004 until June 2011 Lars M. Blank lead the group Systems Biotechnology at the Laboratory of Chemical Biotechnology at the TU Dortmund and was a senior research fellow at the Leibniz-Institut für Analytische Wissenschaften - ISAS - e.V. in Dortmund. In January 2010 he finalized his Habilitation. On the 1st of July 2011 he became professor and head of the Institute of Applied Microbiology at the RWTH Aachen, Germany.

Lars M. Blank focuses in his research on fundamental and applied aspects of microbial metabolism. Of specific interest is the interaction between the metabolic network and the introduced genetic and environmental perturbations. The research on in silico/in vivo metabolic network operation is aimed at a deeper understanding of cell function, with the ultimate goal of rational cell engineering.

In his teaching, Lars M. Blank focuses on the integration of biological concepts with the tools from bioinformatics and engineering. He believes that a sound knowledge base in the life sciences is key for creative and thus successful work in the areas of Metabolic Engineering and Synthetic Biology.
Publications
Peer Reviewed Articles
2016
  • Köhler K. A. K., Blank L. M., Ebert B. E., Rückert C., Kalinowski J. and Schmid A. (2016)
    Genome and physiology of Pseudomonas taiwanensis strain VLB120 reveal a new chassis for industrial biotechnology.
    Submitted
  • Sudarsan S., Blank L. M., Dietrich A, Vielhauer O, Takors R, Schmid A. and Reuss M. (2016)
    Dynamics of benzoate metabolism in Pseudomonas putida KT2440.
    3:97-110
2015
  • Köhler K. A. K., Blank L. M., Frick O. and Schmid A. (2015)
    D-Xylose assimilation via the Weimberg pathway by solvent tolerant Pseudomonas taiwanensis VLB120.
    Environmental Microbiology, 17(1):156-170, DOI-Link
  • Köhler K. A. K., Rühl J., Blank L. M. and Schmid A. (2015)
    Integration of biocatalyst and process engineering for sustainable und efficient n-butanol production.
    Engineering in Life Sciences, 15(1):4-19, DOI-Link
2014
  • Sudarsan S., Dethlefsen S., Blank L. M., Siemann-Herzberg M. and Schmid A. (2014)
    The functional structure of central carbon metabolism.
    Applied and Environmental Microbiology, 80(17):5292-5303 , DOI-Link
2013
  • Köhler K. A. K., Rückert C., Schatschneider S., Vorhölter F., Sczepanowski R., Blank L. M., Niehaus K., Goesmann A., Pühler A., Kalinowski J. and Schmid A. (2013)
    Complete genome sequence of Pseudomonas sp. strain VLB120 a solvent tolerant, styrene degrading bacterium, isolated from forest soil.
    Journal of Biotechnology, 168(4):729-730, DOI-Link
  • Fritzsch F. S. O., Rosenthal K., Kampert A., Howitz S., Dusny C., Blank L. M. and Schmid A. (2013)
    Picoliter nDEP traps enable time-resolved contactless single bacterial cell analysis in controlled microenvironments.
    Lab on a Chip, 13(3):397-408, DOI-Link
  • Falcioni F., Blank L. M., Frick O., Karau A., Bühler B. and Schmid A. (2013)
    Proline availability regulates proline-4-hydroxylase synthesis and substrate uptake in proline-hydroxylating recombinant Escherichia coli.
    Applied and Environmental Microbiology, 79(9):3091-3100, DOI-Link
  • Kuhn D., Fritzsch F. S. O., Zhang X., Wendisch V. F., Blank L. M., Bühler B. and Schmid A. (2013)
    Subtoxic product levels limit the epoxidation capacity of recombinant E. coli by increasing microbial energy demands.
    Journal of Biotechnology, 163(2):194-203, DOI-Link, PubMed
2012
  • Blank L. M., Deshpande R., Schmid A. and Hayen H. (2012)
    Simultaneous analysis of carbon and nitrogen metabolism by ultra-high-resolution mass spectrometry applying 13C- and 15N-labeled substrates simultaneously.
    Analytical and Bioanalytical Chemistry, 403(8):2291-2305, DOI-Link
  • Rühl J., Hein E. M., Hayen H., Schmid A. and Blank L. M. (2012)
    The glycerophospholipid inventory of Pseudomonas putida is conserved between strains and enables growth condition related alterations.
    Microbial Biotechnology, 5(1):45-58, DOI-Link, PubMed
  • Escapa I. F., Garcia J. L., Bühler B., Blank L. M. and Prieto M.A. (2012)
    The polyhydroxyalkanoate metabolism controls carbon and energy spillage in Pseudomonas putida.
    Environmental Microbiology, 14(4):1049-1063, DOI-Link
2011
  • Heyland J., Fu J., Blank L. M. and Schmid A. (2011)
    Carbon metabolism limits recombinant protein production in Pichia pastoris.
    Biotechnology and Bioengineering, 108(8):1942-1953, DOI-Link, PubMed
  • Fritzsch F. S. O., Kortmann H., Lonzynski J., Blank L. M. and Schmid A. (2011)
    Pressure resistant and reversible on-tube-sealing for microfluidics.
    Microfluidics and Nanofluidics, 10(3):679-684, DOI-Link
  • Heyland J., Blank L. M. and Schmid A. (2011)
    Quantification of metabolic limitations during recombinant protein production in Escherichia coli.
    Journal of Biotechnology, 155(2):178-184, DOI-Link, PubMed
  • Ebert B. E., Kurth F., Grund M., Blank L. M. and Schmid A. (2011)
    Response of P. putida KT2440 to increased NADH and ATP demand.
    Applied and Environmental Microbiology, 77(18):6597–6605, DOI-Link, PubMed
  • Kortmann H., Blank L. M. and Schmid A. (2011)
    Single cell analytics: an overview.
    Advances in Biochemical Engineering and Biotechnology, 124:99-122, DOI-Link, PubMed
2010
  • Vickers C. E., Blank L. M. and Krömer J. O. (2010)
    Chassis cells for industrial biochemical production.
    Nature Chemical Biology (Grand Challenge), 6(12):875-877, DOI-Link, PubMed
  • Schmid A., Kortmann H., Dittrich P. and Blank L. M. (2010)
    Chemical and biological single cell analysis.
    Current Opinion in Biotechnology, 21(1):12-20, DOI-Link, PubMed
  • Heck T., Makam S., Lutz J., Blank L. M., Schmid A., Seebach Dieter, Kohler H.-P. E. and Geueke B. (2010)
    Kinetic analysis of L-carnosine formation by beta-aminopeptidases.
    Advanced Synthesis and Catalysis, 352(2-3):407-415, DOI-Link
  • Holm A. K., Blank L. M., Oldiges M., Schmid A., Solem C., Jensen P. R. and Vemuri G. N. (2010)
    Metabolic and transcriptional response to cofactor perturbations in Escherichia coli.
    The Journal of Biological Chemistry, 285(23):17498-17506, DOI-Link, PubMed
  • Blank L. M. and Kuepfer L. (2010)
    Metabolic flux distributions: genetic information, computational predictions, and experimental validation.
    Applied Microbiology and Biotechnology, 86(5):1243-1255, DOI-Link, PubMed
  • Heyland J., Fu J., Blank L. M. and Schmid A. (2010)
    Quantitative physiology of Pichia pastoris during glucose-limited high cell-density fed-batch cultivation for recombinant protein production.
    Biotechnology and Bioengineering, 107(2):357-368, DOI-Link, PubMed
  • Blank L. M., Ebert B. E., Bühler K. and Bühler B. (2010)
    Redox biocatalysis and metabolism: molecular mechanisms and metabolic network analysis.
    Antioxidants & Redox Signaling, 13(3):349-394, DOI-Link, PubMed
  • Heyland J., Antweiler N., Lutz J., Heck T., Geueke B., Kohler H.-P. E., Blank L. M. and Schmid A. (2010)
    Simple enzymatic procedure for carnosine synthesis: whole-cell biocatalysis and efficient biocatalyst recycling.
    Microbial Biotechnology, 3(1):74-83, DOI-Link, PubMed
  • Schmid A. and Blank L. M. (2010)
    Systems biology: Hypothesis-driven omics integration.
    Nature Chemical Biology (News & Views), 6:485-487, DOI-Link, PubMed
  • Kuhn D., Blank L. M., Schmid A. and Bühler B. (2010)
    Systems biotechnology - rational biocatalyst and bioprocess design.
    Engineering in Life Sciences, 10(5):384–397, DOI-Link
2009
  • Kortmann H., Blank L. M. and Schmid A. (2009)
    A rapid, reliable, and automatable interface for microfluidic devices.
    Lab-on-a-Chip, 9:1455 - 1460, DOI-Link, PubMed
  • Heyland J., Fu J. and Blank L. M. (2009)
    Correlation between TCA cycle flux and glucose uptake rate during respiro-fermentative growth of Saccharomyces cerevisiae.
    Microbiology, 155:3827-3837, DOI-Link, PubMed
  • Maddula Sasidhar, Blank L. M., Schmid A. and Baumbach J. I. (2009)
    Detection of volatile metabolites of Escherichia coli by multi capillary column coupled ion mobility spectrometry.
    Analytical and Bioanalytical Chemistry, 394(3):791-800, DOI-Link, PubMed
  • Hein E. M., Blank L. M., Heyland J., Baumbach J. I., Schmid A. and Hayen H. (2009)
    Glycerophospholipid profiling by HPLC/MS using exact mass measurements and MSn fragmentation experiments in parallel.
    Rapid Communications in Mass Spectrometry, 23(11):1636-1646, DOI-Link, PubMed
  • Wierckx N. J. P., Ruijssenaars H. J., de Winde J. H., Schmid A. and Blank L. M. (2009)
    Metabolic flux analysis of a phenol producing mutant of Pseudomonas putida S12: verification and complementation of hypotheses derived from transcriptomics.
    Journal of Biotechnology, 143(2):124–129, DOI-Link, PubMed
  • Rühl J., Schmid A. and Blank L. M. (2009)
    Selected Pseudomonas putida strains able to grow in high concentrations of butanol.
    Applied and Environmental Microbiology, 75(13):4653-4656, DOI-Link, PubMed
  • Kortmann H., Blank L. M. and Schmid A. (2009)
    Single cell analysis reveals unexpected growth phenotype of S. cerevisiae.
    Cytometry: Part A, 75A(2):130-139, DOI-Link, PubMed
  • Kortmann H., Chasanis P., Blank L. M., Franzke J., Kenig E. Y. and Schmid A. (2009)
    The Envirostat - A new bioreactor concept.
    Lab-on-a-Chip, 9:576–585, DOI-Link, PubMed
  • Kortmann H., Kurth F., Blank L. M., Dittrich P. and Schmid A. (2009)
    Towards real time analysis of protein secretion from single cells.
    Lab-on-a-Chip, 9:3047-3049, DOI-Link, PubMed
2008
  • Kurth F., Schumann C. A., Blank L. M., Schmid A., Manz A. and Dittrich P. (2008)
    A bilayer microfluidic chip for diffusion-controlled activation of yeast species.
    Journal of Chromatography A, 1206(1):77-82, DOI-Link, PubMed
  • Blank L. M., Hugenholtz P. and Nielsen L. K. (2008)
    Evolution of the hyaluronic acid synthesis (has) operon in Streptococcus zooepidemicus and other pathogenic streptococci.
    Journal of Molecular Evolution, 67(1):13-22, DOI-Link, PubMed
  • Blank L. M., Ebert B. E., Bühler B. and Schmid A. (2008)
    Metabolic capacity estimation of Escherichia coli as platform for redox biocatalysis: Constraint based modeling and experimental verification.
    Biotechnology and Bioengineering, 100(6):1050-1065, DOI-Link, PubMed
  • Blank L. M., Ionidis G., Ebert B. E., Bühler B. and Schmid A. (2008)
    Metabolic response of Pseudomonas putida during redox biocatalysis in the presence of a second octanol phase.
    FEBS Journal, 275(20):5173-5190, DOI-Link, PubMed
  • Bühler B., Park J. B., Blank L. M. and Schmid A. (2008)
    NADH availability limits asymmetric biocatalytic epoxidation in growing recombinant Escherichia coli.
    Applied and Environmental Microbiology, 74(5):1436-1446, DOI-Link, PubMed
2007
  • Kortmann H., Blank L. M. and Schmid A. (2007)
    Cultivation of dielectrophoretically trapped single cells under optimal environmental conditions.
    Conference paper µTAS 2007, Conference Proceedings, (07.10.-11.10.2007):715-717
  • Koebmann B. J., Blank L. M., Solem C., Petranovic D., Nielsen L. K. and Jensen P. R. (2007)
    Increased biomass yield of Lactococcus lactis during energetically limited growth and respiratory conditions.
    Biotechnology and Applied Biochemistry, 50:25-33, DOI-Link, PubMed
2006
  • Dragan C.-A., Blank L. M. and Bureik M. (2006)
    Increased TCA cycle activity and reduced oxygen consumption during cytrochrome P450-dependent biotransformation in fission yeast.
    Yeast, 23:779-794, DOI-Link, PubMed
2005
  • Blank L. M., Kuepfer L. and Sauer U. (2005)
    Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast.
    Genome Biology, 6(R49), DOI-Link
  • Kuepfer L., Sauer U. and Blank L. M. (2005)
    Metabolic functions of duplicate genes in Saccharomyces cerevisiae.
    Genome Research, 15(10):1421-1430, DOI-Link, PubMed
  • Blank L. M., Lehmbeck F. and Sauer U. (2005)
    Metabolic-flux and network analysis in fourteen hemiascomycetous yeasts.
    FEMS Yeast Research, 5(6-7):545-558, DOI-Link, PubMed
  • Fong Chong B., Blank L. M., McLaughlin R. L. and Nielsen L. K. (2005)
    Microbial hyaluronic acid production.
    Applied Microbiology and Biotechnology, 66(4):341-351, DOI-Link
  • Blank L. M., McLaughlin R. L. and Nielsen L. K. (2005)
    Stable production of hyaluronic acid in Streptococcus zooepidemicus chemostats operated at high dilution rate.
    Biotechnology and Bioengineering, 90(6):685-693, DOI-Link
2004
  • Fredlund E., Blank L. M., Schnürer J., Sauer U. and Passoth V. (2004)
    Oxygen- and glucose-dependent regulation of central carbon metabolism in Pichia anomala.
    Applied and Environmental Microbiology, 70(10):5905-5911, DOI-Link, PubMed
  • Blank L. M. and Sauer U. (2004)
    TCA cycle activity in Saccharomyces cerevisiae is a function of the environmentally determined specific growth and glucose uptake rate.
    Microbiology, 150(4):1085-1093, DOI-Link, PubMed
2001
  • Harris L. M., Blank L. M., Desai R., Welker N. and Papoutsakis E. (2001)
    Fermentation characterization and flux analysis of recombinant strains of Clostridium acetobutylicum with an inactivated solR gene.
    Journal of Industrial Microbiology, 27(5):322-328, DOI-Link, PubMed
  • Blank L. M., Koebmann B. J., Michelsen O., Nielsen L. K. and Jensen P. R. (2001)
    Hemin reconstitutes proton extrusion in an H+-ATPase-negativ mutant of Lactococcus lactis.
    Journal of Bacteriology, 183(22):6707-6709, DOI-Link, Direct-Link
2000
  • Blank L. M., Koebmann B. J., Nielsen L. K. and Jensen P. R. (2000)
    Hemin reconstitutes the growth of an H+-ATPase-negative mutant of Lactococcus lactis.
    9th International BioThermoKinetics Meeting: Animating the Cellular Map, Stellenbosch, South Africa, (Peer-reviewed Proc.)
1999
  • Girzalsky W., Rehling P., Stein K., Kipper J., Blank L. M., Kunau W.-H. and Erdmann R. (1999)
    Involvement of Pex13 in Pex14 localization and peroxisomal targeting signal 2-dependent protein import into peroxisomes.
    Journal of Cell Biology, 144(6):1151-1162, PubMed
  • Harris L. M., Nair R. V., Green E. and Blank L. M. (1999)
    Metabolic engineering and gene regulation in Clostridium acetobutylicum.
    The American Chemical Society, USA, (Peer-reviewed Proc.):217:034-Biot, Part1
1998
  • Huhse B., Rehling P., Albertini M., Blank L. M., Meller K., Kunau W.-H. and Erdmann R. (1998)
    Pex17p of Saccharomyces cerevisiae is a novel peroxin and component of the peroxisomal protein translocation machinery.
    Journal of Cell Biology, 140(1):49-60, PubMed
Books & Bookchapters
2009
  • Blank L. M. (2009)
    Habilitation Thesis: Systems Biotechnology & Biocatalysis.
    TU Dortmund University, Dortmund, Germany
  • Bühler B., Blank L. M., Ebert B. E., Bühler K. and Schmid A. (2009)
    Energy and cofactor issues in fermentation and oxyfunctionalisation processes.
    in Smolke C. D. The metabolic pathway engineering handbook.
    CRC Press, Boca Raton, Florida, USA, Vol. 2:21 1-32, ISBN: 978-1-4200-7765-0
2002
  • Blank L. M. (2002)
    PhD Thesis: The has operon of Streptococcus zooepidemicus: composition, origin and stability.
    University of Queensland, Brisbane, Australia, ISBN: 1864996293
1997
  • Blank L. M. (1997)
    Diploma Thesis: Protein import in peroxisomes of the baker’s yeast Saccharomyces cerevisiae.
    Ruhr University of Bochum, Bochum, Germany
  • Blank L. M. (1997)
    Diploma Thesis: Molecular and fermentation characterization of recombinant strains for metabolic engineering studies of Clostridium acetobutylicum.
    University of Dortmund, Dortmund, Germany
Patent applications
2012
  • Fritzsch F. S. O., Howitz S., Blank L. M. and Schmid A. (2012)
    Method for the separation of polarisable bioparticles.
    PCT/EP2011/057724, filed
2007
  • Karau A., Sieber V., Haas T., Häger H., Grammann K., Bühler B., Blank L. M. and Schmid A. (2007)
    omega-amino carboxylic acids, omega-amino carboxylic acid esters, or recombinant cells which produce lactams thereof.
    WO/2009/077461 / PCT/EP2008/067447 / priority: 102007060705.0 17.12.2007 DE
2002
  • Blank L. M., Koebmann B. J. and Jensen P. R. (2002)
    Method of improving biomass yield of lactic acid bacterial cultures.
    WO 0202747
Oral Presentations
2011
  • Blank L. M. (2011)
    Zukunftsforum - Vorstellung des Papiers "Biotechnologie für Morgen" bioreactors and bioprocesses.
    Deutsche Biotechnologietage 2011, 25. - 26. May 2011, Munich, Germany
  • Blank L. M. (2011)
    Systems Biotechnology & Biocatalysis.
    Visit of the Laboratory of Bioresource Engineering, 24. May 2011, Osaka, Japan
  • Blank L. M., Bühler B., Julsing M. K., Kuhn D., Ebert B. E. and Schmid A. (2011)
    RedoxCell: exploiting microbial metabolism for biocatalytic oxyfunctionalization.
    CLIB Conference, 5. - 6. March 2011, Düsseldorf, Germany
  • Blank L. M., Heyland J., Fu J. and Schmid A. (2011)
    Pichia pastoris: metabolic consequences of recombinant protein production.
    Recombinant Protein Production 6 (RPP6), 16. - 19. February, BOKU, Vienna, Austria
2010
  • Blank L. M. (2010)
    Systembiologische Untersuchungen der Proteinproduktion in Hefen: Einzelzellanalyse und quantitative Physiologie.
    DECHEMA-Kolloqium Mikrobielle Zellfabriken, 9. December 2010, Frankfurt, Germany
  • Blank L. M. (2010)
    Operation of the yeast metabolic network.
    Topical day on bioinformatics, 19. November 2010, Mol, Belgium
  • Blank L. M. (2010)
    Systems Biotechnology & Biocatalysis.
    AIBN institute seminar, 11. November 2010, Brisbane, Australia
  • Blank L. M., Kortmann H., Fritzsch F. S. O., Dusny C. and Schmid A. (2010)
    A new reactor concept - the Envirostat.
    20th Annual Conference of the DGfZ, 13. - 15. October 2010, Leipzig, Germany
  • Blank L. M. (2010)
    From unit operation to functional modules: Biochemical Engineering in the 21st century.
    Tag des BCI, 8. October 2010, Dortmund, Germany
  • Blank L. M., Heyland J., Kortmann H. and Schmid A. (2010)
    Einzelzellanalyse und quantitative Physiologie für die systembiotechnologische Untersuchung der Proteinproduktion in Hefen.
    Jahrestagung der Biotechnologen, 21. - 23. September, Aachen, Germany
  • Blank L. M. (2010)
    Single cell analysis.
    Seminar at the Institute for Microbiology and Biotechnology, Ulm University, 21. June 2010, Ulm, Germany
  • Blank L. M. (2010)
    Is whole-cell redox biocatalysis limited by microbial metabolism?
    Department seminar at the Ewah Womans University, 11. June 2010, Seoul, Korea
  • Blank L. M. (2010)
    Systems Biotechnology & Biocatalysis.
    Seminar of the Department Biochemical and Chemical Engineering, 28. April 2010, TU Dortmund University, Dortmund, Germany
  • Blank L. M., Bühler K., Bühler B. and Schmid A. (2010)
    Pseudomonas sp. strain VLB120: a versatile bacterium.
    VAAM, 28. - 31. March 2010, Hannover, Germany
  • Blank L. M. (2010)
    Interplay of protein production and carbon metabolism in Pichia pastoris: a Systems Biotechnology approach.
    Seminar of the Research Center Applied Biocatalysis, 4. March 2010, Graz, Austria
  • Blank L. M. (2010)
    Interplay of protein production and carbon metabolism in Pichia pastoris.
    Seminar at the Vienna Institute of BioTechnology (VIBT) of the BOKU, 2. March 2010, Vienna, Austria
  • Blank L. M. (2010)
    Synthetische Biologie: Konzepte, Beispiele und Verheissungen.
    Seminar of the Department Biochemical and Chemical Engineering, 13. January 2010, TU Dortmund University, Dortmund, Germany
2009
  • Blank L. M., Ebert B. E., Bühler B. and Schmid A. (2009)
    Performance estimation of redox biocatalysis using metabolic models.
    DECHEMA Jahrestagung der Biotechnologen, 8. - 10. September 2009, Mannheim, Germany
  • Blank L. M. (2009)
    Development of a single cell analysis platform.
    Seminar of the Institute of Biotechnology, 1. July 2009, Jülich, Germany
  • Blank L. M. (2009)
    From Systems to Synthetic Biotechnology.
    Biofine 2009, 16. - 17. April 2009, Freiburg, Germany
  • Blank L. M., Rühl J., Ebert B. E., Bühler B. and Schmid A. (2009)
    Solvent tolerant Pseudomonas: platform organisms for whole-cell biocatalysis?
    VAAM, 08.-11. March 2009, Bochum, Germany
  • Blank L. M., Fraatz M., Schmid A. and Zorn H. (2009)
    Quantitative physiology of the basidiomycete Pleurotus sapidus.
    VAAM, 8.-11. March 2009, Bochum, Germany
  • Blank L. M. (2009)
    Single cell analysis.
    Seminar of the Research Center Applied Biocatalysis, 2. March 2009, Graz, Austria
2008
  • Blank L. M. (2008)
    Is whole-cell redox biocatalysis limited by microbial metabolism?
    Seminar of the Kluyver Center, 16. July 2008, Delft, The Netherlands
  • Blank L. M. (2008)
    Analysis of metabolism by metabolomics and fluxomics.
    Biochemistry Summer School “Regulation of metabolism and metabolic disorders”, 29. June - 6. July, Trabzon, Turkey
  • Blank L. M. (2008)
    Quantitative yeast physiology.
    Seminar of the Molecular Microbiology Department, 23. May 2008, Leuven, Belgium
  • Blank L. M., Sudarsan S. and Schmid A. (2008)
    Metabolic network robustness.
    BIOSYSBIO08 Imperial College, 20.-22. April 2008, London, England
  • Blank L. M., Ebert B. E., Sudarsan S. and Schmid A. (2008)
    Quantification of metabolic network robustness of Escherichia coli during anaerobic growth.
    VAAM, 9. - 11. March 2008, Frankfurt, Germany
  • Blank L. M. (2008)
    Whole-cell redox biocatalysis: in silico and in vivo analysis.
    Department seminar of the Kompetenzzentrum Biokatalyse, TU Graz, 5. March 2008, Graz, Austria
2007
  • Blank L. M. (2007)
    Performance estimation of redox biocatalysis on (single) cell level.
    Penn State University, 21. December 2007, State College, PA, USA
  • Blank L. M. (2007)
    Metabolic characterization of yeast by flux and single cell analysis.
    Modular Genetics, 19. December 2007, Boston, MA, USA
  • Blank L. M. (2007)
    Deciphering metabolic network robustness.
    University of Boston, 17. December 2007, Boston, MA, USA
  • Blank L. M. (2007)
    Animating metabolic networks.
    Joint Genome Institute, 13. December 2007, Walnut Creek, CA, USA
  • Blank L. M. (2007)
    Metabolic characterization of yeast by flux and single cell analysis.
    VH-Conference, 23. - 24. April 2007, Berlin, Germany
  • Blank L. M., Kortmann H. and Schmid A. (2007)
    A single cell analysis platform for Saccharomyces cerevisiae.
    VAAM, 1. - 4. April 2007, Osnabrück, Germany
  • Blank L. M., Ionidis G., Bühler B., Ebert B. E. and Schmid A. (2007)
    Quantification of microbial redox metabolism for biocatalysis by metabolic network analysis.
    VAAM, 1. - 4. April 2007, Osnabrück, Germany
  • Blank L. M. (2007)
    Performance estimation of redox biocatalysis on the (single) cell level.
    PREACH, 21. March 2007, Dortmund, Germany
  • Blank L. M. (2007)
    Microbial Metabolism: Basic concepts and applications.
    Department Seminar of the 'Kompetenzzentrum Biokatalyse', 13. March 2007, University of Graz, Austria
2006
  • Blank L. M. (2006)
    Produktion und erstmaliger Einsatz von β-Aminopeptidasen zur umweltfreundlichen Biosynthese von β-Peptiden als Intermediate für die Herstellung innovativer Pharmaka.
    Kick-Off meeting of ChemBioTec, 20. November 2006, Deutsche Bundesstiftung Umwelt Osnabrück, Germany
  • Blank L. M. (2006)
    Metabolic characterisation of yeast by flux and single cell analysis.
    Seminar of the Institute of Physiological Chemistry, 23. October 2006, Ruhr-University Bochum, Germany
  • Blank L. M. and Schmid A. (2006)
    Intracellular carbon flux analysis in biocatalytic active microbes.
    Achema, 15. - 19. May 2006, Frankfurt, Germany
  • Blank L. M., Ebert B. E., Bühler B. and Schmid A. (2006)
    Metabolic capacity estimation of Escherichia coli for conenzyme dependent asymmetric epoxidation.
    VAAM, 19. - 22. March 2006, Jena, Germany
  • Blank L. M. (2006)
    Stochiometric models for metabolic network analysis of microbes.
    Institute for Cancer Research and Treatment, 14. March 2006, Torino, Italy
2005
  • Blank L. M. (2005)
    Stochiometric models for metabolic network analysis.
    CompBioNets05, 5. - 7. December 2005, Lyon, France
  • Blank L. M. and Schmid A. (2005)
    Metabolomics for white biotechnology.
    InterAction, 9. - 10. November 2005, Basel, Switzerland
Posters
2012
  • Rosenthal K., Fritzsch F. S. O., Dusny C., Frick O., Blank L. M. and Schmid A. (2012)
    An Overview: Microbioreactors and Analytics for Systems biology on Single Cell Level.
    2nd BioProScale Symposium, 14. - 16. March 2012, Berlin, Germany
  • Fritzsch F. S. O., Oehling V., Rosenthal K., Dusny C., Kampert A., Kortmann H., Frick O., Blank L. M. and Schmid A. (2012)
    Contactless single cell analysis of industrial relevant bacteria in controlled microenvironments.
    2nd BioProScale Symposium, 14. - 16. March 2012, Berlin, Germany
  • Köhler K. A. K., Walter K., Lang K., Müller B., Hoffrogge R., Blank L. M. and Schmid A. (2012)
    Eliminating drawbacks of recombinant n-butanol production by Pseudomonas sp. VLB120: identification of alcohol and aldehyde dehydrogenases involved in butanol metabolization.
    3rd annual CLIB-graduate cluster retreat, 22. - 24. February 2012, Bergisch-Gladbach, Germany
2011
  • Rosenthal K., Fritzsch F. S. O., Dusny C., Frick O., Blank L. M. and Schmid A. (2011)
    Single Cell Analysis in Biotechnology A: An Overview: From defined Microenvironments towards Systems Biology.
    Bubble Tech to Bio App – LAB-ON-A-CHIP, 17. - 18. October 2011, Saarbruecken, Germany
  • Fritzsch F. S. O., Rosenthal K., Dusny C., Kampert A., Kortmann H., Frick O., Blank L. M. and Schmid A. (2011)
    Single Cell Analysis in Biotechnology B: The Envirostat 2.0 – A next generation microfluidic platform for single cell analysis in controlled microenvironments.
    Bubble Tech to Bio App – LAB-ON-A-CHIP, 17. - 18. October 2011, Saarbruecken, Germany
  • Dusny C., Fritzsch F. S. O., Rosenthal K., Parolina G., Oehling V., Frick O., Blank L. M. and Schmid A. (2011)
    Single Cell Analysis in Biotechnology C: Time-resolved quantitative physiology of trapped single yeast and bacteria in defined microenvironments.
    Bubble Tech to Bio App – LAB-ON-A-CHIP, 17. - 18. October 2011, Saarbruecken, Germany
  • Falcioni F., Frick O., Blank L. M., Schmid A. and Bühler B. (2011)
    Relationship between cell physiology and biocatalytic activity in E. coli expressing proline-4-hydroxylase.
    Biotrans 2011, 2. - 6. October 2011, Giardini Naxos, Sicily, Italy
  • Dusny C., Fritzsch F. S. O., Kortmann H., Blank L. M. and Schmid A. (2011)
    Towards quantitative physiology with single yeast.
    bio.dortmund, 28. September 2011, Dortmund, Germany
  • Fritzsch F. S. O., Dusny C., Kortmann H., Blank L. M. and Schmid A. (2011)
    Single cell analysis.
    Nano! Nutzen und Visionen einer neuen Technology, DASA, 15. July 2011, Dortmund, Germany
  • Köhler K. A. K., Malekina T., Blank L. M. and Schmid A. (2011)
    Optimization of biobutanol production: metabolic engineering and solvent tolerance.
    2nd Annual CLIB-graduate cluster retreat, 7. April 2011, Bonn, Germany
  • Köhler K. A. K., Malekina T., Blank L. M. and Schmid A. (2011)
    Optimization of biobutanol production: Metabolic engineering and solvent tolerance.
    2nd CLIB international conference, 5. April 2011, Düsseldorf, Germany
  • Dusny C., Fritzsch F. S. O., Blank L. M. and Schmid A. (2011)
    Towards quantitative physiology with single yeast (Best poster award).
    Leibniz-Institute for Analytical Sciences – ISAS - e. V. Summer School 2011, 07. July 2011, Dortmund, Germany
2010
  • Kuhn D., Zhang X., Fritzsch F. S. O., Blank L. M., Schmid A. and Bühler B. (2010)
    Systems biotechnological approach for intensification of a biocatalytic oxyfunctionalization process.
    ESBES (European Symposium on Biochemical Engineering Science), 5. - 8. September 2010, Bologna, Italy
  • Rühl J., Blank L. M. and Schmid A. (2010)
    Pseudomonas putida as host for biobutanol production.
    BioTrends 2010, 1. - 2. December 2010, Dortmund, Germany
  • Falcioni F., Frick O., Blank L. M., Schmid A. and Bühler B. (2010)
    Microbial physiology determines the catalytic efficiency of proline hydroxylation by proline-4-hydroxylase.
    BioTrends 2010, 1. - 2. December 2010, Dortmund, Germany
  • Fritzsch F. S. O., Dusny C., Kortmann H., Blank L. M. and Schmid A. (2010)
    Single Cell Analysis.
    ISAS - Evaluation, 30. September 2010, Dortmund, Germany
  • Blank L. M., Ebert B. E. and Schmid A. (2010)
    Analysis, design and optimization of bacterial networks for redox biocatalysis.
    Metabolic Engineering conference, 13. - 18. June 2010, Jeju, Korea
  • Blank L. M., Heyland J., Fu J. and Schmid A. (2010)
    Protein production with Pichia pastoris: Is metabolism limiting?
    VAAM, 28. - 31. March 2010, Convention Center Hannover, Germany
  • Escapa I. F., Nogales J., Díaz E., Bühler B., Blank L. M. and Prieto M.A. (2010)
    Influence of polyhydroxyalkanoate content on central carbon metabolism operation of Pseudomonas putida KT2442.
    Systems Biology of Microorganisms, 22. - 24. March 2010, Paris, France
  • Köhler K. A. K., Blank L. M. and Schmid A. (2010)
    Optimization of biobutanol production: Metabolic engineering and solvent tolerance.
    1st Annual CLIB-graduate cluster retreat, 8. March 2010, Wuppertal, Germany
  • Falcioni F., Frick O., Blank L. M., Schmid A. and Bühler B. (2010)
    Interrelation between α-ketoglutarate dependent proline hydroxylation and metabolic network operation in recombinant E. coli.
    Gordon Research Conference on Biocatalysis, 11. - 16. July 2010, Smithfield, RI, USA
2009
  • Heyland J., Blank L. M. and Schmid A. (2009)
    Production of L-carnosine using recombinant whole cell biocatalysts.
    DECHEMA Jahrestagung der Biotechnologen, 8. - 10. September 2009, Mannheim, Germany
  • Rühl J., Blank L. M. and Schmid A. (2009)
    Selected P. putida strains can grow in the presence of high butanol concentrations.
    DECHEMA Jahrestagung der Biotechnologen, 8. - 10. September 2009, Mannheim, Germany
  • Lutz J., Lang K., Heck T., Geueke B., Kohler H.-P. E., Blank L. M. and Schmid A. (2009)
    Towards enzymatic production of carnosine.
    Biotrans 2009, 5. - 9. July 2009, Bern, Switzerland
  • Lutz J., Lang K., Lange K., Blank L. M. and Schmid A. (2009)
    Synthesis of carnosine using β-peptidases.
    ProStab2009 - 8th International Conference on Protein Stabilisation, 14. - 17. April 2009, Graz, Austria
  • Fritzsch F. S. O., Kortmann H., Blank L. M. and Schmid A. (2009)
    A reliable, rapid and easy-to-use world-to-chip interface.
    11th Status Seminar Chip Technologies, DECHEMA, 5.-6. March, Frankfurt, Germany
  • Fritzsch F. S. O., Kortmann H., Blank L. M. and Schmid A. (2009)
    The single cell ENVIROSTAT.
    ISAS - Scientific Consultant Meeting, 06. July 2009, Dortmund, Germany
  • Schmid A., Fritzsch F. S. O., Kortmann H. and Blank L. M. (2009)
    The single cell Envirostat.
    Gordon Research Conference on Applied & Environmental Microbiology, 12. - 17. July, South Hadley, MA, USA
2008
  • Rühl J., Blank L. M. and Schmid A. (2008)
    Solvent tolerant Pseudomonas: towards engineering of an improved biocatalyst for biobutanol production.
    Metabolic Engineering VII, 14.-19. September, Puerto Vallarta, Mexico
  • Kortmann H., Blank L. M. and Schmid A. (2008)
    The ENVIROSTAT - a new bioreactor concept for studying single cell physiology.
    Metabolic Engineering VII, 14.-19. September, Puerto Vallarta, Mexico
  • Kortmann H., Blank L. M. and Schmid A. (2008)
    The ENVIROSTAT - a new reactor concept for single cell physiology.
    4th Int. Conference on Analysis of Microbial Cells at the Single Cell Level, 22.-24. May 2008, Bad Schandau, Germany
  • Kurth F., Schumann C. A., Kortmann H., Blank L. M., Schmid A., Manz A. and Dittrich P. (2008)
    A bilayer microfluidic chip for diffusion-controlled activation of yeast species.
    Methods for Systems Biology MSB08, 9. - 13. March 2008, Berlin, Germany
  • Ebert B. E., Blank L. M. and Schmid A. (2008)
    Genome-scale metabolic model of Pseudomonas putida KT2440.
    VAAM, 9. - 11. March 2008, Frankfurt/Main, Germany
  • Geltenpoth H., Hein E. M., Blank L. M., Schmid A. and Hayen H. (2008)
    In-depth analysis of baker's yeast metabolism: central carbon metabolism.
    Methods for Systems Biology MSB08, 9. - 13. March 2008, Berlin, Germany
  • Hein E. M., Blank L. M., Schmid A. and Hayen H. (2008)
    In-depth analysis of baker's yeast metabolism: glycerophospholipids.
    Methods for Systems Biology MSB08, 9. - 13. March 2008, Berlin, Germany
  • Blank L. M., Hein E. M., Schmid A. and Hayen H. (2008)
    In-depth analysis of baker's yeast metabolism: metabolic fluxes.
    Methods for Systems Biology MSB08, 9. - 13. March 2008, Berlin, Germany
  • Rühl J., Blank L. M. and Schmid A. (2008)
    Quantitative analysis of glucose utilization by Pseudomonas putida KT2440.
    VAAM, 9. - 11. March 2008, Frankfurt, Germany
  • Kortmann H., Blank L. M. and Schmid A. (2008)
    The Envirostat - precise environmental controlled cultivation on μscale.
    Methods for Systems Biology MSB08, 9. - 13. March 2008, Berlin, Germany
  • Hein E. M., Blank L. M., Schmid A. and Hayen H. (2008)
    Phospholipid profiling of yeast.
    PittCon 2008, 2. - 7. March 2008, New Orleans, USA
  • Ebert B. E., Blank L. M. and Schmid A. (2008)
    Genome-scale metabolic model of Pseudomonas putida KT2440.
    2nd International Symposium on Biothermodynamics, 21. - 22. February 2008, Frankfurt/Main, Germany
  • Wierckx N. J. P., Blank L. M., de Winde H., Schmid A. and Ruijssenaars H. J. (2008)
    Metabolic flux analysis of a phenol producing mutant of Pseudomonas putida S12.
    Kluyver Center, 29. - 30. January 2008, Delft, The Netherlands
2007
  • Kortmann H., Blank L. M. and Schmid A. (2007)
    Cultivation of dielectrophoretically trapped single cells under optimal environmental conditions.
    11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, 7. - 11. October 2007, Paris, France
  • Bühler B., Kuhn D., Park J. B., Blank L. M. and Schmid A. (2007)
    Evaluation of the efficiency of recombinant Escherichia coli as an epoxidation catalysts by a systems biotechnology approach.
    Biotrans 2007 - 8th International Symposium on Biocatalysis and Biotransformations, 8. - 13. July 2007, Ovideo, Spain
  • Kortmann H., Blank L. M. and Schmid A. (2007)
    A single cell analysis platform for Saccharomyces cerevisiae.
    European BioPerspectives, 30. May - 1. June 2007, Cologne, Germany
  • Blank L. M., Ionidis G., Bühler B. and Schmid A. (2007)
    Estimation of the microbial redox cofactor regeneration rate.
    European BioPerspectives, 30. May - 1. June 2007, Cologne, Germany
  • Ebert B. E., Blank L. M., Bühler B. and Schmid A. (2007)
    Metabolic capacity estimation of Escherichia coli as platform for redox biocatalysis.
    European BioPerspectives, 30. May - 1. June 2007, Cologne, Germany
  • Heyland J., Blank L. M. and Schmid A. (2007)
    Metabolic flux analysis in Saccaromyces cerevisiae based on 13C labeled proteinogenic amino acids of the secretome.
    European BioPerspectives, 30. May - 1. June 2007, Cologne, Germany
  • Ebert B. E., Blank L. M., Bühler B. and Schmid A. (2007)
    Using constraint-based modeling to estimate Escherichia colis capacity for redox biocatalysis.
    2nd FEBS Advanced Lecture Course on Systems Biology, 11. - 16. March 2007, Gosau, Austria
  • Kortmann H., Blank L. M. and Schmid A. (2007)
    Establishing a single cell bioreactor for Saccaromyces cerevisiae.
    Statusseminar Chiptechnologien, 1. - 2. February 2007, Frankfurt, Germany
2006
  • Kortmann H., Blank L. M. and Schmid A. (2006)
    Single cell analysis.
    Bioband, 16. October 2006, Dortmund, Germany
  • Blank L. M., Ebert B. E., Bühler B. and Schmid A. (2006)
    Metabolic capacitiy of biocatalytic active microbes.
    6th Metabolic Engineering Conference, 1. - 5. October 2006, Nordwijkerhout, Netherlands
  • Blank L. M., Ebert B. E., Bühler B. and Schmid A. (2006)
    Constrained based modelling for metabolic capacity estimation of Escherichia coli as platform for redox biocatalysis.
    From µl to m3 - Strategies in bioprocess development, 28. - 29. March 2006, Hamburg, Germany
  • Blank L. M., Ionidis G., Bühler B. and Schmid A. (2006)
    Quantitative physiology of microbes; metabolic capacitiy of Pseudomonas putida for biocatalysis.
    20th International Symposium on Micro-Scale Bioseparations, 21. - 25. January 2006, Amsterdam, Netherlands
2005
  • Blank L. M., Ionidis G. and Schmid A. (2005)
    Metabolic capacity of Pseudomonas putida as biocatalyst inferred from 13C tracer experiments.
    3rd International Conference on Analysis of Microbial Cells at Single Cell Level, 26. - 28. May 2005, Semmering, Austria


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